Ivan D'orso, PhD

Assistant Professor
Microbiology
Graduate Program: Biological Chemistry
Molecular Microbiology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-633-0015
Office Fax: 214-648-5905

ivan.dorso@utsouthwestern.edu

Education

Graduate SchoolNational University of San Martin - Argentina, Molecular Biology (2003)
UndergraduateNational University of Mar Del Plata - Argentina (1998)

Research Interests

Biochemistry
HIV/AIDS
Host-pathogen interactions
Protein-protein interactions
Protein-RNA complexes
Transcription regulation

Publications

Featured
RNA-mediated displacement of an inhibitory snRNP complex activates transcription elongation.

D'Orso I, Frankel AD, Nature structural & molecular biology, 2010 Jul; 17 (7):815-21

Transcription control by long non-coding RNAs.

Faust T, Frankel A, D'Orso I, Transcription, 2012 Mar; 3 (2)

Global landscape of HIV-human protein complexes.

Jäger S, Cimermancic P, Gulbahce N, Johnson JR, McGovern KE, Clarke SC, Shales M, Mercenne G, Pache L, Li K, Hernandez H, Jang GM, Roth SL, Akiva E, Marlett J, Stephens M, D'Orso I, Fernandes J, Fahey M, Mahon C, O'Donoghue AJ, Todorovic A, Morris JH, Maltby DA, Alber T, Cagney G, Bushman FD, Young JA, Chanda SK, Sundquist WI, Kortemme T, Hernandez RD, Craik CS, Burlingame A, Sali A, Frankel AD, Krogan NJ, Nature, 2012 Jan; 481 (7381):365-70

Purification and characterization of HIV-human protein complexes.

Jäger S, Gulbahce N, Cimermancic P, Kane J, He N, Chou S, D'Orso I, Fernandes J, Jang G, Frankel AD, Alber T, Zhou Q, Krogan NJ, Methods (San Diego, Calif.), 2011 Jan; 53 (1):13-9

HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear.

D'Orso I, Frankel AD, Viruses, 2010 Oct; 2 (10):2226-2234

Host cell factors in HIV replication: meta-analysis of genome-wide studies.

Bushman FD, Malani N, Fernandes J, D'Orso I, Cagney G, Diamond TL, Zhou H, Hazuda DJ, Espeseth AS, König R, Bandyopadhyay S, Ideker T, Goff SP, Krogan NJ, Frankel AD, Young JA, Chanda SK, PLoS pathogens, 2009 May; 5 (5):e1000437

Tat acetylation modulates assembly of a viral-host RNA-protein transcription complex.

D'Orso I, Frankel AD, Proceedings of the National Academy of Sciences of the United States of America, 2009 Mar; 106 (9):3101-6

Targeting tat inhibitors in the assembly of human immunodeficiency virus type 1 transcription complexes.

D'Orso I, Grunwell JR, Nakamura RL, Das C, Frankel AD, Journal of virology, 2008 Oct; 82 (19):9492-504

Honors/Awards

NIH/NIAID K99/R00 Pathway to Independence Award, USA

(2009)

amfAR Postdoctoral Fellow

Inaugural Mathilde Krim Fellowship to support bright young scientist for AIDS Research (2008)

Human Frontier Science Program (HFSP) Postdoctoral Fellow

2004-2008 (2004)

Sixth Young Talent Prize - Amersham-Pharmacia, Brazil

(2002)

Research in Health Science prize, Argentina

(2000)