George DeMartino, PhD

Professor
Endowed Title: Robert W. Lackey Professorship in Physiology
Physiology
Graduate Program: Biological Chemistry
Integrative Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-645-6000

george.demartino@utsouthwestern.edu

Education

Graduate SchoolUniversity of Rochester (1976)
UndergraduateUnion College (1971)

Research Interests

Calpains
Intracellular protein degradation
Muscle growth and atrophy
Proteasome
Ubiquitin and ubiquitin-like proteins

Publications

Featured
Real-time detection of ERAD substrate retro-translocation in a mammalian in vitro system.

Wahlman, J, DeMartino, GN, Skach, WR, Bulleid, NJ, Brodsky, JL and Johnson, AE , Cell , 2007; (129):943-955

Featured
VCP is a regulator of ER stress involved in the degradation of multiple substrates of the ubiquitin-proteasome system in mammalian cells.

Wojcik C, Rowicka, M, Kudlicki, A, Nowis, D, Adams, GM, Kujawa, M, and DeMartino GN , Mol Biol Cell , 2006; (17):4606-4618

Featured
ATP binding and ATP hydrolysis play distinct roes in the function of 26S proteasome.

Liu, C, Li, X, Thompson, D, Wooding, K, Chang, T, Tang, Z, Yu, H, Thomas, PJ, and DeMartino, GN , Mol Cell , 2006; (24):39-50

Featured
Endoproteolytic activity of the proteasome.

Liu, CW, Corboy, MJ, DeMartino, GN, and Thomas, PJ , Science , 2003; (299):408-411

Featured
Identification, purification, and characterization of a high molecular weight ATP-dependent activator (PA700) of the 20S proteasome.

Ma, C-P, Vu, JH, Proske, RJ, Slaughter, CA, and DeMartino, GN , J Biol Chem , 1994; (269):3539-3547

Featured
Identification, purification and characterization of a protein activator (PA28) of the 20S proteasome (macropain).

Ma, C-P, Slaughter, CA, and DeMartino, GN , J Biol Chem , 1992; (267):10515-10523

RNA interference of VCP reveals multiple cellular roles linked to ubiquitin-proteasome dependent proteolysis.

Wojcik, C, Yano, M, and DeMartino, GN , J Cell Sci , 2004; (117):281-92

The latent form of macropain (high molecular weight multicatalytic protease) restores ATP-dependent proteolysis to cell-free extracts of BHK fibroblasts pretreated with antimacropain antibodies.

McGuire, MJ, McCullough, ML, Croall, DE, and DeMartino, GN , Biochim Biophys Acta , 1989; (995):181-186

Identification and partial purification of an ATP-stimulated alkaline protease in rat liver.

DeMartino, GN and Goldberg, AL , J Biol Chem , 1979; (254):3712-3715

Honors/Awards

Visiting Professor

University of Coimbra Medical School, Coimbra, Portugal (2005)

Leon L. Miller Lecturer

University of Rochester School of Medicine (2003)

Chair, FASEB Summer Research Conferenc

Ubiquitin and Intracellular Protein Degradation (2001)

Outstanding Teacher Award, Southwestern Medical School

2003-2005, 2008

The Robert W. Lackey Professorship in Physiology

1996 - Present

Professional Associations/Affiliations

American Association for the Advancement of Science

American Physiological Society

American Society for Biological Chemistry and Molecular Biology

American Society for Cell Biology