James de Lemos, MD

Professor
Endowed Title: Sweetheart Ball - Kern Wildenthal, M.D., Ph.D., Distinguished Chair in Cardiology
Internal Medicine

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390


Office Fax: 214-645-7501

james.delemos@utsouthwestern.edu

To make an appointment, call 214-645-8300.

Biography

 Dr. de Lemos is Professor of medicine and holds the Sweetheart Ball-Kern Wildenthal, MD, PhD Distinguished Chair in Cardiology.  He is the Cardiology Service Chief at Parkland Memorial Hospital where he also serves as CCU Director.  He was the director of the Cardiology Fellowship at UT Southwestern from 2005-2011. He is an active investigator in the Donald W. Reynolds Cardiovascular Research Center at UT Southwestern, and the Medical Director of the Dallas Heart Study.   He has chaired or co-chaired several research planning committees at UT Southwestern.  His primary research interests are in early detection, risk assessment and management of cardiovascular disease, with a particular focus on the role of cardiovascular biomarkers.  His research has evaluated existing biomarkers such as B-type natriuretic peptide, C-reactive protein and cardiac troponins as well as novel biomarkers reflecting biological pathways of disease.  He was the lead author of the Z phase of the A to Z trial, an international trial investigating different cholesterol lowering strategies in patients with acute coronary syndromes.  He graduated from Harvard Medical School and completed an Internal Medicine Residency at UT Southwestern Medical Center, where he also served as Chief Medical Resident.  He completed a fellowship in Cardiovascular Medicine and served on the faculty at the Brigham and Women’s Hospital before returning to UT Southwestern Medical School.  He has served on multiple committees of the AHA and ACC and is on the editorial board of the Journal of the American College of Cardiology, the American Journal of Cardiology and the American Heart Journal.  He has mentored >25 post-doctoral research trainees and has authored or coauthored over 250 manuscripts or book chapters and won several teaching awards. He sees patients with a broad range of cardiac problems, but specializes in those with chest pain and coronary artery disease.

Education

FellowshipHarvard Medical School, Cardiology (1999)
Chief ResidentUT Southwestern Medical Center at Dallas, Internal Medicine (1996)
ResidencyUT Southwestern Medical Center at Dallas, Internal Medicine (1995)
InternshipUT Southwestern Medical Center at Dallas, Internal Medicine (1993)
Medical SchoolHarvard Medical School (1992)

Research Interests

Acute Coronary Sydromes
Cardiac Biomarkers
Lipid Lowering Therapy
Screening for Cardiovascular Disease

Publications

Featured
Impact of body weight and extreme obesity on the presentation, treatment, and in-hospital outcomes of 50,149 patients with ST-Segment elevation myocardial infarction results from the NCDR (National Cardiovascular Data Registry).

Das SR, Alexander KP, Chen AY, Powell-Wiley TM, Diercks DB, Peterson ED, Roe MT, de Lemos JA, Journal of the American College of Cardiology, 2011 Dec; 58 (25):2642-50

Featured
Biomarkers in clinical trials: can we move from fortune telling to disease profiling?

de Lemos JA, McGuire DK, Circulation, 2011 Aug; 124 (6):663-5

Featured
Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population.

de Lemos JA, Drazner MH, Omland T, Ayers CR, Khera A, Rohatgi A, Hashim I, Berry JD, Das SR, Morrow DA, McGuire DK, JAMA : the journal of the American Medical Association, 2010 Dec; 304 (22):2503-12

Featured
Early Intensive vs a Delayed Conservative Simvastatin Strategy in Patients With Acute Coronary Syndromes: Phase Z of the A to Z Trial

46. de Lemos JA, Blazing MA, Wiviott SD, Lewis EF, Fox KA, White HD, Rouleau JL, Pedersen TR, Gardner LH, Mukherjee R, Ramsey KE, Palmisano J, Bilheimer DW, Pfeffer MA, Califf RM, Braunwald E , JAMA , 2004; (292):1303-17

Featured
Enoxaparin versus unfractionated heparin in patients treated with tirofiban, aspirin and an early conservative initial management strategy: results from the A phase of the A to Z trial

47. de Lemos JA, Blazing MA, Wiviott SD, Brady WE, White HD, Fox KAA, Palmisano J, Ramsey KE, Bilheimer D, Lewis EF, Califf RM, Braunwald E , Eur Heart J , 2004; (25):1688-94

Featured
The prognostic value of B-type natriuretic peptide in patients with acute coronary syndromes

de Lemos JA, Morrow DA, Bentley JH, Omland T, Sabatine MS, McCabe CH, Hall C, Cannon CP, Braunwald E , New England Journal of Medcine , September 2001; (345):1014-21

Low levels of circulating troponin as an intermediate phenotype in the pathway to heart failure.

de Lemos JA, Grundy SM, Journal of the American College of Cardiology, 2012 Jan; 59 (5):490-2

Association of growth differentiation factor-15 with coronary atherosclerosis and mortality in a young, multiethnic population: observations from the Dallas Heart Study.

Rohatgi A, Patel P, Das SR, Ayers CR, Khera A, Martinez-Rumayor A, Berry JD, McGuire DK, de Lemos JA, Clinical chemistry, 2012 Jan; 58 (1):172-82

No free lunches: balancing bleeding and efficacy with ticagrelor.

de Lemos JA, Brilakis ES, European heart journal, 2011 Dec; 32 (23):2919-21

Race-specific associations of myeloperoxidase with atherosclerosis in a population-based sample: the Dallas Heart Study.

Chen LQ, Rohatgi A, Ayers CR, Das SR, Khera A, Berry JD, McGuire DK, de Lemos JA, Atherosclerosis, 2011 Dec; 219 (2):833-8

Books

Biomarkers in Heart Disease

de Lemos JA, Blackwell Publishing2008

Cardiovascular Therapeutics: A companion to Braunwald's Heart Disease, 3rd ed

de Lemos JA, Saunders2007

Hurst's the Heart, 13th ed (Unstable Angina and Non-ST Elevation Myocardial Infarction)

de Lemos JA, O'Rourke RA, Harrington RA, McGraw Hill2011

Irwin and Rippe?s Intensive Care Medicine 7th edition (ST Elevation Myocardial infarction)

de Lemos JA and Morrow DA, William and Wilkins 2011

Honors/Awards

Simon Dack Award for Medical Publications

Journal of the American College of Cardiology (2012)

Association of University Cardiologists

(2011)

Best Doctors in Dallas, Cardiology

D Magazine (2011)

Core Clerkship Teaching Award

UT Southwestern (2011)

Super Doctors, Cardiology

Texas Monthly (2011)

Best Doctors in Dallas, Cardiology

D Magazine (2010)

Super Doctors, Cardiology

Texas Monthly (2010)

Sweetheart Ball-Kern Wildenthal MD, PhD Dintinguished Chair

Distinguished Chair in Cardiology (2009)

Elite Reviewer

Journal of the American College of Cardiology (2006)

Best Doctors in Dallas, Cardiology

D Magazine (2005)

Internal Medicine Teaching Award

Excellence in Teaching (2005)

Eugene Braunwald Fellowship

Excellence in Clinical Research, Brigham and Women’s Hospital (1999)

Soma Weiss Award

Excellence in Teaching, Brigham and Women’s Hospital (1997)

Professional Associations/Affiliations

Society of Chest Pain Physicians

Board of Trustees (2011)

AHA/ACC ST Elevation MI Guideline Committee

(2010-2012)

Chair, Research and Publications Committee

ACTION Registiry-GWTG (2010)

American Heart Association

Fellow (1998)

American College of Cardiology

Fellow (1996)