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Laurie Davis, PhD
Contact Information
UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390
Biography
Dr. Davis is currently a member of the Department of Internal Medicine and Harold C. Simmons Arthritis Research Center and faculty of the Immunolgy Graduate Program. The Davis laboratory has focused on mechanisms regulating T lymphocyte activation and differentiation. The laboratory has also developed an interest in the altered immune responses observed in patients with autoimmune diseases.
The laboratory currently has two main areas of investigation. First, the researchers are interested in understanding human CD4+ T cell differentiation and cytokine production. These studies evaluate the influences, such as antigen-presenting cells, that direct T helper cell differentiation. Other studies attempt to examine the role of CD4+ T cells in the perpetuation of chronic inflammatory diseases. A second area of investigation involves the search for new markers of human autoimmunity and disease severity. For these studies, both innate and immune subsets of blood cells from patients with autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus and multiple sclerosis are compared to healthy controls by gene expression profiling and extensive phenotyping. These studies will elucidate molecular pathways that are altered by autoimmune diseases and could identify novel therapeutic targets.
Education
| Graduate School | University of Texas Southwestern Med Ctr Dallas, Molecular Immunology (1987) |
| Undergraduate | Lamar University-Beaumont, Biology (1979) |
Research Interests
Publications
LS Davis, M Sackler, RI Brezinschek, E Lightfoot, JL Bailey, N Oppenheimer-Marks, PE Lipsky , Amer J Pathol , 2002; (160):357-367
H Schulze-Koops, PE Lipsky, and LS Davis , European Journal of Immunology , 1998; (28):2517-2529
LS Davis, AF Kavanaugh, LA Nichols and PE Lipsky , Journal of Immunology , 1995; (154):3523-3537
Ireland SJ, Blazek M, Harp CT, Greenberg B, Frohman EM, Davis LS, Monson NL, Autoimmunity, 2012 Apr;
Chowdhury FZ, Ramos HJ, Davis LS, Forman J, Farrar JD, Blood, 2011 Oct; 118 (14):3890-900
Davis LS, Bhutani S, Barnett SR, Khan DA, Clinical and molecular allergy : CMA, 2011 ; 9:12
Wang A, Guilpain P, Chong BF, Chouzenoux S, Guillevin L, Du Y, Zhou XJ, Lin F, Fairhurst AM, Boudreaux C, Roux C, Wakeland EK, Davis LS, Batteux F, Mohan C, Arthritis and rheumatism, 2010 Nov; 62 (11):3436-46
A Luong, LS Davis and BF Marple , Amer J Rhinology , 2009; ((in press))
AM Davis, HJ Ramos, LS Davis and JD Farrar , J Immunol , December 2008; (181):8204-8208
J Hutcheson, JC Scatizzi, AM Siddiqui, GK Haines 3rd, T Wu, QZ Li, LS Davis, C Mohan and H Perlman. , Immunity , February 2008; (28):206-217