Jennifer Cuthbert, MD

Professor
Internal Medicine

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

jennifer.cuthbert@utsouthwestern.edu

To make an appointment, call 214-645-8300.

Biography

Dr. Cuthbert obtained her medical degree (M.B.B.S.) from the University of Sydney (1973) and undertook internship and residency in medicine and one year of Gastroenterology training at teaching hospitals of the University of Sydney (1973-1976). Between 1977 and 1981, she completed a clinical research fellowship in hepatology and a basic research fellowship in immunology in the Department of Internal Medicine at UT Southwestern. In 1992, Dr. Cuthbert was awarded the M.D. from the University of Sydney for a thesis entitled "The Role of Lipid Metabolism in Human T Lymphocyte Proliferation".

Education

FellowshipParkland Memorial Hospital, Hepatology (1981)
FellowshipRoyal Prince Alfred Hospital, Gastroenterology (1976)
ResidencySydney Hospital, Internal Medicine (1975)
Medical SchoolUniversity of Sydney Australia (1973)
InternshipRoyal North Shore Hospital, Internal Medicine (1973)

Research Interests

Ascites and complications of liver disease
Jaundice and acute hepatitis
Medical education
Web Curriculum http://medschool.swmed.edu

Publications

Featured
Regulation of hepatic sterol metabolism in the rat: Parallel regulation of activity and mRNA for 7alpha-hydroxylase but not 3-hydroxy-3-methylglutaryl coenzyme A reductase or low density lipoprotein receptor

Spady DK and JA Cuthbert , J Biol Chem , 1992; (267):5584-5591

Featured
Negative regulation of cell proliferation by mevalonate or one of the mevalonate phosphates

Cuthbert JA and PE Lipsky , J Biol Chem , 1991; (266):17966-17971

Featured
Inhibition by 6-fluoromevalonate demonstrates that mevalonate or one of the mevalonate phosphates is necessary for lymphocyte proliferation

Cuthbert JA and PE Lipsky , J Biol Chem , 1990; (265):18568-18575

Featured
Regulation of low density lipoprotein receptor gene expression in human lymphocytes

Cuthbert JA, DW Russell and PE Lipsky , J Biol Chem , 1989; (264):1298-1304

Featured
Detection of familial hypercholesterolemia by assaying functional low-density-lipoprotein receptors on lymphocytes

Cuthbert JA, CA East, DW Bilheimer and PE Lipsky , N Engl J Med , 1986; (314):879-883

Hepatitis A: Ancient disease, emerging threat? A modern review with historical emphasis

Cuthbert JA , Clin Microbiol Rev , 2001; (14):38-58

Multiple mechanisms, independent of sterol regulatory element binding proteins, can control low density lipoprotein gene transcription

Makar RSJ, PE Lipsky and JA Cuthbert , J Lipid Res , 2000; (41):762-774

Sterol-independent, sterol response element-dependent regulation of low density lipoprotein receptor gene expression

Makar RSJ, PE Lipsky and JA Cuthbert , J Lipid Res , 1998; (39):1647-1654

Overexpression of cholesterol 7alpha-hydroxylase (CYP7A) in mice lacking the low density lipoprotein (LDL) receptor gene. LDL transport and plasma LDL concentrations are reduced.

Spady DK, JA Cuthbert, MN Willard and RS Meidell , J Biol Chem , 1998; (273):126-132

Wilson's disease: Update on a systemic disorder with protean manifestations.

Cuthbert JA , Gastroenterol Clin North Am , 1998; (27):655-682

Honors/Awards

Distinguished Teaching Professor

(2006)

Southwestern Academy of Teachers

Founding member (2006)

UT Academy of Health Science Education

Founding member (2005)

D Magazine - Best Doctor

1999, 2005, 2008, 2009

Professional Associations/Affiliations

American Association for the Study of Liver Disease