Christopher Doern, PhD

Assistant Professor
Pathology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-456-1344

christopher.doern@utsouthwestern.edu

Biography

I am the medical director of clinical microbiology at Children's Medical Center of Dallas and assistant professor of Pathology at UTSouthwestern Medical Center.  I took my position as director upon completing a fellowship in Medical and Public Health Microbiology at Washington University in St. Louis in 2010.  I am board certified by the American Board of Medical Microbiology (ABMM). 

In addition to providing medical direction for the microbiology laboratory I am actively pursuing several research interests.  My research interests include the development of molecular tools for the rapid diagnosis of infectious diseases.  This includes implementation and application of new and emerging technologies that promise to improve our ability to diagnose disease in a rapid manner.  I am particularly interested in assessing the utility of these technologies to discover how they can best be used to improve patient care and impact physician decision making.  I am also interested in studying the changing epidemiology of bacterial antibiotic resistance in pediatrics.  Of particular interest is understanding the emergence of resistant Gram negative organisms.  Lastly, I actively participate in FDA clinical trials which cover a broad array of diagnostic methodologies such as blood culturing, respiratory virus testing and molecular diagnostics.

Education

Graduate SchoolWake Forest University, Microbiology (2008)
UndergraduateWake Forest University, Biology (2003)

Research Interests

Antibacterial resistance in pediatrics
Laboratory test utilization
Molecular diagnostics

Publications

Featured
It's not easy being green: the viridans group streptococci, with a focus on pediatric clinical manifestations.

Doern CD, Burnham CA, Journal of clinical microbiology, 2010 Nov; 48 (11):3829-35

Evaluation of Spectra VRE, a new chromogenic agar medium designed to screen for vancomycin-resistant Enterococcus faecalis and Enterococcus faecium.

Peterson JF, Doern CD, Kallstrom G, Riebe KM, Sander T, Dunne WM, Ledeboer NA, Journal of clinical microbiology, 2010 Dec; 48 (12):4627-9

Loss of the group A Streptococcus regulator Srv decreases biofilm formation in vivo in an otitis media model of infection.

Roberts AL, Connolly KL, Doern CD, Holder RC, Reid SD, Infection and immunity, 2010 Nov; 78 (11):4800-8

Evaluation of a chromogenic agar under development to screen for VRE colonization.

Kallstrom G, Doern CD, Dunne WM, Journal of clinical microbiology, 2010 Mar; 48 (3):999-1001

Biofilm formation by group A Streptococcus: a role for the streptococcal regulator of virulence (Srv) and streptococcal cysteine protease (SpeB).

Doern CD, Roberts AL, Hong W, Nelson J, Lukomski S, Swords WE, Reid SD, Microbiology (Reading, England), 2009 Jan; 155 (Pt 1):46-52

Point mutations within the streptococcal regulator of virulence (Srv) alter protein-DNA interactions and Srv function.

Doern CD, Holder RC, Reid SD, Microbiology (Reading, England), 2008 Jul; 154 (Pt 7):1998-2007

Inactivation of the group A Streptococcus regulator srv results in chromosome wide reduction of transcript levels, and changes in extracellular levels of Sic and SpeB.

Reid SD, Chaussee MS, Doern CD, Chaussee MA, Montgomery AG, Sturdevant DE, Musser JM, FEMS immunology and medical microbiology, 2006 Nov; 48 (2):283-92

Macrolide-resistant Streptococcus pyogenes in the United States, 2002-2003.

Richter SS, Heilmann KP, Beekmann SE, Miller NJ, Miller AL, Rice CL, Doern CD, Reid SD, Doern GV, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2005 Sep; 41 (5):599-608