David Corey, PhD

Professor
Pharmacology, Biochemistry
Graduate Program: Biological Chemistry
Cancer Biology
Molecular Biophysics
Download Curriculum Vitae

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-645-6155
Office Fax: 214-645-6138

david.corey@utsouthwestern.edu

Biography

Dr. David R. Corey was born in Cambridge. Mass., August 13, 1963. He received his BA degree in Chemistry from Harvard University in 1985, and his PhD in Chemistry from the University of California at Berkeley in 1990. He completed postdoctoral training with Dr. Charles Craik in the Department of Pharmaceutical Chemistry at the University of California at San Francisco (1990-1992). In 1992 Dr. Corey joined the faculty of the Department of Pharmacology at the University of Texas Southwestern Medical Center at Dallas as an Assistant Professor. In 1996 Dr. Corey recieved a secondary appointment to the Department of Biochemistry, and in 1998 he was promoted to Associate Professor and to Full Professor in 2003.

Education

Graduate SchoolUniversity of California-Berkeley (1990)

Research Interests

antigene oligonucleotides
antisense oligonucleotides
Nucleic acids
RNAi
Telomerase

Publications

Featured
Regulation of transcription by small RNAs complementary to sequences downstream from the 3? termini of genes.

Yue, X., Schwartz, J. C., Younger, S. T., Chu, Y., Gagnon, K.T., Elbashir, S., Janowski, B. A., Corey, D. R. , Nature Chemical Biology , Summer 2010; (6):621-629

Featured
Inhibition of mutant huntingtin expression by targeting mutant RNA structure.

Hu, J., Matsui, M., Gagnon, K. T., Schwartz, J. C., Gabillet, S., Arar, K., Wu, J., Bezprozvanny, I., and Corey, D. R. , Nature Biotechnology , Summer 2009; (27):478-484

Featured
Inhibiting transcription of chromosomal DNA using antigene peptide nucleic acids.

Janowski, B. A., Kaihatsu, K., Huffman, K. E., Schwartz, J. C., Ram, R., Hardy, D., Mendelson, C. R., and Corey D. R. , Nature Chemical Biology , Summer 2005; (1):210-215

Featured
Allele-selectivity by switching to an miRNA-like RNAi mechanism.

Hu, J., Liu, J., and Corey, D. R. , Chem. Biol. , December 2010; (17):1183-1187

Featured
Antisense transcripts are targets for small activating RNAs

Schwartz, J. C., Younger, S. T., Nguyen, N-B., Hardy, D. B., Corey, D. R., and Janowski, B. A. , Nature Structural and Molecular Biology , 2008; (8/15):842-849

Ago1 and Ago2 link mammalian transcriptional silencing with RNAi.

Janowski, B. A., Huffman, K. E., Schwartz, J. C., Ram, R., Nordsell, R., Shames, D. S., Minna, J. D., and Corey, D. R. , Nature Structural and Molecular Biology , Summer 2006; (13):787-792

Inhibiting gene expression at transcription start sites in chromosomal DNA by antigene RNAs

Janowski, B. A., Huffman, K. E., Schwartz, J. C., Ram, R., Hardy, D., Shames, D. S., Minna, J. D., and Corey D. R. , Nature Chemical Biology , September 2005; (1):216-222

Activating gene expression in mammalian cells with promoter-targeted duplex RNAs

Janowski, B. A., Younger, S. T., Hardy, D. B., Ram, R., Huffman, K. E., and Corey, D. R. , Nature Chemical Biology , 2007; (3):166-173

Antigene inhibition by peptide nucleic acids and duplex RNAs

Janowski, B. A., Hu, J., and Corey, D. R. , Nature Protocols , 2006; (1):436-433

Inhibition of telomerase leads to eroded telomeres, reduced proliferation, and cell death

Herbert, B-S., Pitts, A. E., Baker, S. I., Hamilton, S. E., Wright, W. E., Shay, J. W. and Corey, D. R. , Proc. Natl. Acad. Sci. USA , 1999; (96):14726-14781

Honors/Awards

Excellence Postdoctoral Mentoring Award

(2010)

McKnight Neuroscience Award

(2009)

Welch Lectueship

(2003)

CaP Cure Research Award

(1996)

Damon Runyon Postdoctoral Fellowship

(1990)

Professional Associations/Affiliations

American Cancer Society

American Chemical Society

American Society of Pharmacology & Experimental Therapeutics