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Burton Combes, MD
Endowed Title: Ashbel Smith Professor
Contact Information
UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390
Biography
Dr. Combes obtained his AB degree from Columbia College (1947) and his MD degree from Columbia University College of Physicians and Surgeons (1951). After completing his internship and residency in Internal Medicine at Columbia, he completed three years of postdoctoral training with Stanley E. Bradley at Columbia, and one year at University College Hospital Medical School in London before joining the faculty of medicine at UT Southwestern in 1957.
In the area of hepatology, Dr. Combes has special interests in autoimmune liver disease, including autoimmune hepatitis and primary biliary cirrhosis. He also has long-standing interests in liver diseases occurring during pregnancy. For the past decade, Dr. Combes has been heavily committed to assessments of ursodeoxycholic acid (UDCA) and methotrexate in the treatment of primary biliary cirrhosis (PBC). He has been principal investigator of a multicenter, randomized, double-blind clinical trial of UDCA versus placebo in the treatment of PBC; and since 1993, has been principal investigator of an NIH-supported multicenter trial of UDCA plus methotrexate versus UDCA plus placebo in the treatment of PBC. Dr. Combes is also involved in more basic studies concerned with the immunopathogenesis of PBC.
Education
| Medical School | Columbia University Central Office (1951) |
| Undergraduate | Columbia University Central Office (1947) |
Research Interests
Publications
Combes B, Luketic VA, Peters MG, Zetterman RK, et al , Am J Gastroenterology , 2004; (99):264-268
Browning J, Combes B, and Mayo MJ , Am J Gastroenterology , 2003; (98):2736-2741
Mayo MJ, Lipsky PE, Miller SN, Stastny P, and Combes B , Dig Dis Sci , 2001; (46):345-357
Combes B, Markin RS, Wheeler DE, Rubin R, et al , Hepatology , 1999; (30):602-605
Mayo MJ, Jenkins RN, Combes B and Lipsky P , Hepatology , 1999; (29):1635-1642
Related Links
Honors/Awards
University of Texas Southwestern Medical School, 1982-present
American Association for the Study of Liver Diseases and the American Liver Foundation, 1984
National Institute of Arthritis, Metabolism and Digestive Diseases, 1975-1979
American Association for the Study of Liver Diseases, 1971
University of Texas Southwestern Medical School, 1972-1974