Melanie Cobb, PhD

Professor
Endowed Title: Jane and Bill Browning Jr. Chair in Medical Science
Pharmacology
Graduate Program: Cancer Biology
Cell Regulation

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-645-6122
Office Fax: 214-645-6124

melanie.cobb@utsouthwestern.edu

Biography

Melanie Cobb received her undergraduate degree in biochemistry from the University of Chicago and her PhD in biological chemistry from Washington University in St. Louis in the laboratory of Garland Marshall. Following postdoctoral work with Ora Rosen at the Albert Einstein College of Medicine in New York, she joined the Department of Pharmacology at UT Southwestern Medical Center in Dallas where she is currently a Professor and the holder of the Jane and Bill Browning, Jr Chair in Medical Science. Her interests are in cellular regulatory mechanisms.

Education

Graduate SchoolWashington University (1976)

Research Interests

cancer biology
protein kinase structure/function
regulation of nutrient responses
signal transduction mechanisms
vesicular trafficking

Publications

Featured
TAOs mediate activation of p38 in response to DNA damage.

M. Raman, S. Earnest, K. Zhang, Y. Zhao, and M.H. Cobb. , EMBO J. , 2007; (26):2005-2014

Featured
Starvation activated MAPK through the muscarinic acetylcholine pathway in Caenorhabitis elegans pharynx

Y-j. You, J. Kim, M. Cobb, and L. Avery. , Cell Metabolism , 2006; (3):237-245

Featured
WNK1 phosphorylates synaptotagmin 2 and regulates its ability to associate with membrane vesicles.

B-H. Lee, X. Min, B-e. Xu, S. Chen, H. Shu, E.J. Goldsmith, and M.H. Cobb. , Molecular Cell , 2004; (15):741-751

Featured
Activation mechanism of the MAP kinase ERK2 by dual phosphorylation.

B.J. Canagarajah, A. Khokhlatchev, M.H. Cobb, and E.J. Goldsmith. , Cell , 1997; (90):859-869

Featured
ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF.

T.G. Boulton, S.H. Nye, D.J. Robbins, N.Y. Ip, E. Radziejewska, S.D. Morgenbessor, R.A. DePinho, N. Panayotatos, M.H. Cobb and G.D. Yancopoulos. , Cell , 1991; (65):663-675

WNK 1 is required for mitosis and abscission.

S-W. Tu, K. Luby-Phelps and M.H. Cobb. , Proc. Natl, Acad. Sci. USA , 2011; (108):1385-1390

Regulation of CCAAT-enhancer binding protein homologous protein (CHOP) expression by interleukin 1 beta in pancreatic beta cells.

C. Shao, M.C. Lawrence and M.H. Cobb. , J. Biol. Chem , 2010; (285):19710-19719

Calcineurin increases glucose activation of ERK1/2 by reversing negative feedback.

L. Duan and M.H. Cobb. , Proc. Natl. Acad. Sci. USA , 2010; (107):22314-22319

Radial spoke protein 3 is a mammalian A kinase anchoring protein that binds ERK1/2

A. Jivan, S. Earnest, Y.C. Juang, and M.H. Cobb. , J. Biol Chem. , 2009; (284):29437-29445

Multiple chromatin-bound protein kinases assemble factors that regulate insulin gene transcription.

M.C. Lawrence, C. Shao, K. McGlynn, B. Naziruddin, M.F. Levy, and M.H. Cobb. , Proc. Natl, Acad Sci. USA , 2009; (106):22181-22186