William Kraus, PhD

Professor
Endowed Title: Cecil H. and Ida Green Distinguished Chair in Reproductive Biology Sciences
Obstetrics & Gynecology, Pharmacology
Graduate Program: Integrative Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-2388
Office Fax: 214-648-0383

lee.kraus@utsouthwestern.edu

Biography

W. Lee Kraus, PhD, is the Director of the Cecil H. and Ida Green Center for Reproductive Biology Sciences. He is also Professor and Vice Chair for Basic Sciences in the Department of Obstetrics and Gynecology, and a Professor in the Department of Pharmacology. Dr. Kraus also holds the Cecil H. and Ida Green Distinguished Chair in Reproductive Biology Sciences.

Dr. Kraus did his graduate research on the regulation of steroid hormone receptor activity in the laboratory of Dr. Benita S. Katzenellenbogen at the University of Illinois, Urbana-Champaign and received his PhD in 1994.

He did his postdoctoral research on the mechanisms of transcriptional regulation with chromatin in the laboratory of Dr. Jim Kadonaga at the University of California, San Diego. During his postdoctoral work, Dr. Kraus was supported by fellowships from the National Institutes of Health and the American Cancer Society, California Division.

Prior to joining the faculty at UT Southwestern, Dr. Kraus was a professor in the Department of Molecular Biology and Genetics at Cornell University in Ithaca. He also held a joint appointment in the Department of Pharmacology at the Weill Medical College of Cornell University in New York City.

Dr. Kraus has been supported by a Career Award in the Biomedical Sciences/Reproductive Biology from the Burroughs Wellcome Fund, as well as grants from the National Institutes of Health, the American Cancer Society, the Endocrine Society, and the National Science Foundation.

Education

Graduate SchoolUniversity of Illinois Urbana Campus, Physiology (1994)
Graduate SchoolUniversity of Illinois Urbana Campus, Physiology (1991)
UndergraduateCornell University (1989)

Research Interests

Cancer biology (esp. breast cancer)
Chromatin structure and gene regulation
Hormonal signaling
Molecular physiology of reproduction, inflammation, and adipogenesis

Publications

Featured
A rapid, extensive, and transient transcriptional response to estrogen signaling in breast cancer cells.

Hah N, Danko CG, Core L, Waterfall JJ, Siepel A, Lis JT, Kraus WL, Cell, 2011 May; 145 (4):622-34

Featured
PARP-1 regulates chromatin structure and transcription through a KDM5B-dependent pathway.

Krishnakumar R, Kraus WL, Molecular cell, 2010 Sep; 39 (5):736-49

Featured
The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets.

Krishnakumar R, Kraus WL, Molecular cell, 2010 Jul; 39 (1):8-24

Featured
The histone variant macroH2A1 marks repressed autosomal chromatin, but protects a subset of its target genes from silencing.

Gamble MJ, Frizzell KM, Yang C, Krishnakumar R, Kraus WL, Genes & development, 2010 Jan; 24 (1):21-32

Featured
Reciprocal binding of PARP-1 and histone H1 at promoters specifies transcriptional outcomes

Krishnakumar R., Gamble M. J., Frizzell K. M., Berrocal J. G., Kininis M., and Kraus W. L. , Science , 2008; (319):819-821

Featured
Selective recognition of distinct classes of coactivators by a ligand-inducible activation domain

Acevedo M. L., Lee K. C., Stender J. D., Katzenellenbogen B. S., Kraus W. L. , Molecular Cell , 2004; (13):725-738

Featured
Modulation of chromatin structure and transcription by nucleosome-binding properties of PARP-1

Kim M. Y., Mauro S. A., Gevry N., Lis J. T., Kraus W. L. , Cell , 2004; (119):803-814

Genome-wide analysis reveals PADI4 cooperates with Elk-1 to activate c-Fos expression in breast cancer cells.

Zhang X, Gamble MJ, Stadler S, Cherrington BD, Causey CP, Thompson PR, Roberson MS, Kraus WL, Coonrod SA, PLoS genetics, 2011 Jun; 7 (6):e1002112

Multiple sequence-specific DNA-binding proteins mediate estrogen receptor signaling through a tethering pathway.

Heldring N, Isaacs GD, Diehl AG, Sun M, Cheung E, Ranish JA, Kraus WL, Molecular endocrinology (Baltimore, Md.), 2011 Apr; 25 (4):564-74

Honors/Awards

Cecil H. and Ida Green Distinguished Chair in Reproductive Biology Sciences

(2010)

Cornell University College of Agriculture and Life Sciences Excellence in Mentoring Undergraduate Students in Independent Research Award

(2008)

Richard E. Weitzman Memorial Award from the Endocrine Society

(2007)

Distinguished Alumni Award from the Department of Molecular and Integrative Physiology, University of Illinois, Urbana-Champaign

(2006)

Cornell University College of Agriculture and Life Sciences Young Faculty Teaching Excellence Award

(2004)

Burroughs Wellcome Fund Career Award in the Biomedical Sciences, Reproductive Biology

(1998)