Diego Castrillon, MD, PhD

Associate Professor
Pathology
Graduate Program: Cancer Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-4032
Office Fax: 214-648-7355

diego.castrillon@utsouthwestern.edu

To make an appointment, call 214-645-8300.

Education

FellowshipBrigham & Women's Hospital, Pathology (1999)
ResidencyBrigham & Women's Hospital, Pathology (1998)
InternshipBrigham & Women's Hospital, Pathology (1997)
Medical SchoolUT Southwestern Medical Center at Dallas (1996)
Medical SchoolUT Southwestern Medical Center at Dallas, Genetics and Development (1994)

Research Interests

LKB1 Tumor Suppressor in Women's Cancers
PI3K-FOXO and mTOR pathways
Stem Cells and Infertility

Publications

Featured
Foxo1 is required in mouse spermatogonial stem cells for their maintenance and the initiation of spermatogenesis.

Goertz MJ, Wu Z, Gallardo TD, Hamra FK, Castrillon DH, The Journal of clinical investigation, 2011 Sep; 121 (9):3456-66

Featured
Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy.

Contreras CM, Akbay EA, Gallardo TD, Haynie JM, Sharma S, Tagao O, Bardeesy N, Takahashi M, Settleman J, Wong KK, Castrillon DH, Disease models & mechanisms, 2010 Mar-Apr; 3 (3-4):181-93

Featured
Somatic LKB1 mutations promote cervical cancer progression.

Wingo SN, Gallardo TD, Akbay EA, Liang MC, Contreras CM, Boren T, Shimamura T, Miller DS, Sharpless NE, Bardeesy N, Kwiatkowski DJ, Schorge JO, Wong KK, Castrillon DH, PloS one, 2009 ; 4 (4):e5137

Featured
Foxo3 is a PI3K-dependent molecular switch controlling the initiation of oocyte growth.

John GB, Gallardo TD, Shirley LJ, Castrillon DH, Developmental biology, 2008 Sep; 321 (1):197-204

Featured
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.

Paik JH, Kollipara R, Chu G, Ji H, Xiao Y, Ding Z, Miao L, Tothova Z, Horner JW, Carrasco DR, Jiang S, Gilliland DG, Chin L, Wong WH, Castrillon DH, DePinho RA, Cell, 2007 Jan; 128 (2):309-23

Featured
Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a.

Castrillon DH, Miao L, Kollipara R, Horner JW, DePinho RA, Science (New York, N.Y.), 2003 Jul; 301 (5630):215-8

Honors/Awards

American Society for Clinical Investigation

Member (2009)

National Institutes of Health

Mouse Pathobiologist Award (2007)

Kimmel Scholar Award in Translational Science

Sidney Kimmel Foundation for Cancer Research (2004)

Damon Runyon Postdoctoral Fellowship

Damon Runyon Cancer Research Foundation (2000)

Stanley L. Robbins Research Award

Brigham & Women Hospital / Harvard Medical School (1999)

Professional Associations/Affiliations

American Association for Cancer Research

American Association for the Advancement of Science

American Society for Clinical Investigation

International Society for Stem Cell Research

Society for the Study of Reproduction