Are You a Faculty Member?
If you are a faculty member and would like to make a change to your faculty profile, please login to Profile+ with your UT Southwestern Id and password. Questions? Please email Web Services at webservices@utsouthwestern.edu.
Jen Liou, PhD
Endowed Title: Sowell Family Scholar in Medical Research 2009-2013
Contact Information
UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390
Office Phone: 214-648-1981
Office Fax: 214-645-6049
Biography
Dr. Jen Liou received her PhD in Microbiology and Immunology from University of California at San Francisco (UCSF), under the mentorship of Dr. Arthur Weiss, for her work on dissecting signaling transduction events in lymphocyte activation using biochemical and genetic approaches. During her postdoctoral training under Dr. Tobias Meyer at Stanford University, Dr. Liou studied cellular signaling using systems biology and quantitative live-cell imaging approaches.
She collaborated with four colleagues and generated an siRNA library targeting 2,304 human signaling proteins. She used this library to address a long-standing question in lymphocyte activation and calcium signaling: the molecular mechanism underlying store-operated calcium (SOC) signaling.
Dr. Liou identified STIM1/2 as the calcium sensors in the endoplasmic reticulum for SOC signaling and characterized the activation mechanisms of STIM1/2. Her work represented a major breakthrough that set the direction of many laboratories in the field.
An article in the Summer 2009 edition of Stanford Medicine, "Anatomy of an Experiment: Chasing Down the Cell’s Gatekeepers" describes Dr. Liou’s research.
Education
| Graduate School | University of California-San Francisco, Biology (2001) |
| Graduate School | National Taiwan University - Taiwan, Zoology (1994) |
| Undergraduate | National Taiwan University - Taiwan, Zoology (1992) |
Research Interests
Publications
Liou J*, Fivaz M, Inoue T, Meyer T* [*: Co-corresponding authors] , Proc. Natl. Acad. Sci. USA , May 2007; (104):9301-06
Liou J, Kim ML, Heo WD, Jones JT, Myers JW, Ferrell JE Jr, Meyer T. , Current Biology , July 2005; (15):1235-41
Brandman O, Liou J, Park WS, Meyer T. , Cell , December 2007; (131):1327-39
Liou J, Kiefer F, Dang A, Hashimoto A, Cobb MH, Kurosaki T, Weiss A. , Immunity , 2000; (12):399-408
Liou J*, Fivaz M, Inoue T, Meyer T* [*: Co-corresponding authors] , Proc. Natl. Acad. Sci. USA , May 2007; (104):9301-06
Liou J, Kim ML, Heo WD, Jones JT, Myers JW, Ferrell JE Jr, Meyer T , Current Biology , July 2005; (15):1235-41
Brandman O, Liou J, Park WS, Meyer T. , Cell , December 2007; (131):1327-39
Galvez T, Teruel MN, Heo WD, Jones JT, Kim ML, Liou J, Myers JW, Meyer T. , Genome Biol. , 2007; (8):R142
Related Links
Honors/Awards
UT Southwestern Medical Center (2009)