David Wang, MD, PhD

Assistant Professor
Internal Medicine

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

david1.wang@utsouthwestern.edu

To make an appointment, call 214-645-8300.

Education

Graduate SchoolJohns Hopkins School of Medicine (2009)
FellowshipJohns Hopkins Hospital, Oncology (2009)
FellowshipJohns Hopkins Hospital, Medical Oncology (2004)
ResidencyJohns Hopkins Hospital, Internal Medicine (2002)
InternshipJohns Hopkins Hospital, Internal Medicine (2000)
Medical SchoolVanderbilt University, MOHS Surgery (1999)

Research Interests

Barrett's esophagus
Esophageal cancer
Gastric cancer
Hedgehog signaling
Molecularly targeted therapy

Publications

Featured
Malignant transformation of non-neoplastic Barrett’s epithelial cells through well-defined genetic manipulations.

X Zhang, C Yu, K Wilson, HY Zhang, SD Melton, X Huo, DH Wang, RM Genta, SJ Spechler, RF Souza , PLOS One , September 2010; (5 (9)):e13093

Featured
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53 dependent DNA damage responses.

WY Chen, DH Wang, RC Yen, J Luo, W Gu, SB Baylin , Cell , November 2005; (123 (3)):437-48

Featured
Aberrant epithelial-mesenchymal hedgehog signaling characterizes Barrett’s metaplasia.

DH Wang, NJ Clemons, T Miyashita, AJ Dupuy, W Zhang, A Szczepny, IM Corcoran-Schwartz, DL Wilburn, EA Montgomery, JS Wang, NA Jenkins, NA Copeland, JW Harmon, WA Phillips, DN Watkins , Gastroenterology , May 2010; (138(5)):1810-22

Featured
Acid and bile salt-induced CDX2 expression differs in esophageal squamous cells from patients with and without Barrett’s Esophagus.

X Huo, HY Zhang, XI Zhang, JP Lynch, ED Strauch, JY Wang, SD Melton, RM Genta, DH Wang, SJ Spechler, RF Souza , Gastroenterology , July 2010; (139 (1)):194-203

Featured
A novel Smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-β signal transduction.

RH Kim, D Wang, M Tsang, J Martin, C Huff, MP de Caestecker, WT Parks, X Meng, RJ Lechleider, T Wang, AB Roberts , Genes and Development , July 2000; (14 (13)):1605-16

Biology of Barrett’s esophagus and esophageal adenocarcinoma.

DH Wang, RF Souza , Gastrointestinal Endoscopy Clinics of North America , January 2011; (21 (1)):25-38

The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain.

MP de Caestecker, T Yahata, D Wang, WT Parks, S Huang, CS Hill, T Shioda, AB Roberts, RJ Lechleider , The Journal of Biological Chemistry , January 2000; (275 (3)):2115-22

Epigenetic inactivation of the canonical Wnt antagonist Sry-box containing gene 17 in colorectal cancer.

W Zhang, SC Glockner, M Guo, EO Machida, DH Wang, H Easwaran, L Van Neste, JG Herman, KE Schuebel, DN Watkins, N Ahuja, SB Baylin , Cancer Research , April 2008; (68 (8)):2764-72

Cancer-related inflammation and Barrett’s carcinogenesis: Interleukin-6 and STAT3 mediate apoptotic resistance in transformed Barrett’s cells.

HY Zhang, Q Zhang, X Zhang, C Yu, X Huo, E Cheng, DH Wang, SJ Spechler, RF Souza , American Journal of Physiology. Gastrointestinal and Liver Physiology. , 2011; ((In press))

Honors/Awards

NCI

National Research Service Award (2006)

American Society of Clinical Oncology

Young Investigator Award (2005)

The Endocrine Society

Medical Student Achievement Award (1999)

Howard Hughes Medical Institute

Continued Fellowship for Medical Studies (1998)

Professional Associations/Affiliations

American Association for Cancer Research

American Gastroenterological Association

American Society of Clinical Oncology