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Michael Brown, MD
Endowed Title: W.A. (Monty) Moncrief Distinguished Chair in Cholesterol and Arteriosclerosis Research
Regental Professorship
Paul J. Thomas Chair in Medicine
Integrative Biology
Contact Information
UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390
Office Phone: 214-648-2141
Office Fax: 214-648-8804
Biography
Michael S. Brown received a BA degree in Chemistry in 1962 and an MD degree in 1966 from the University of Pennsylvania. He was an intern and resident at the Massachusetts General Hospital, and a postdoctoral fellow with Dr. Earl Stadtman at the National Institutes of Health. In 1971, he came to UT Southwestern where he rose through the ranks to become a professor in 1976. He is currently Paul J. Thomas Professor of Molecular Genetics and Director of the Jonsson Center for Molecular Genetics at UT Southwestern.
Dr. Brown and his long-time colleague, Dr. Joseph L. Goldstein, together discovered the low density lipoprotein (LDL) receptor, which controls the level of cholesterol in blood and in cells. They showed that mutations in this receptor cause Familial Hypercholesterolemia, a disorder that leads to premature heart attacks in one out of every 500 people in most populations. They have received many awards for this work, including the U.S. National Medal of Science and the Nobel Prize for Medicine or Physiology.
Education
| Medical School | University of Pennsylvania (1966) |
| Undergraduate | University of Pennsylvania (1962) |
Research Interests
Publications
Goldstein, J.L., DeBose-Boyd, R.A. and Brown, M.S. , Cell , 2006; (124):35-46
Brown, M.S., Ye, J., Rawson, R.B., and Goldstein, J.L. , Cell , 2000; (100):391-398
Brown, M.S. and Goldstein, J.L. , Cell , May 1997; (89):331-340
Reiss, Y., Goldstein, J.L., Seabra, M.C., Casey, P.J., and Brown, M.S. , Cell , 1990; (62):81-88
Brown, M.S., and Goldstein, J.L. , Science , April 1986; (232):34-47
Zhao, T.-J., Sakata, I., Li, R.L., Liang, G., Richardson, J.A., Brown, M.S., Goldstein, J.L., and Zigman, J.M. , Proc. Natl. Acad. Sci. USA , 2010; (107):15868-15873
Li, S., Brown, M.S. and Goldstein, J.L. , Proc. Natl. Acad. Sci. USA , 2010; (107):3441-3446
Brown, M.S., Ye, J., and Goldstein, J.L. , Science , 2010; (328):1495-1496
Zhao, T.-J., Liang, G., Li, R.L., Xie, X., Sleeman, M.W., Murphy, A.J., Valenzuela, D.M., Yancopoulos, G.D., Goldstein, J.L., and Brown, M.S. , Proc. Natl. Acad. Sci. USA , 2010; (107):7467-7472
Wang, M.L., Motamed, M., Infante, R.E., Abi-Moshel, L., Kwon, H.J., Brown, M.S. and Goldstein, J.L. , Cell Metab. , 2010; (12):166-173
Related Links
Honors/Awards
(2003)
(2000)
(1988)
(1985)
(1985)