Vincent Aguirre, MD, PhD

Assistant Professor
Internal Medicine

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

vincent.aguirre@utsouthwestern.edu

To make an appointment, call 214-645-8300.

Education

FellowshipMassachusetts General Hospital, Gastroenterology (2008)
ResidencyBrigham & Women's Hospital, Internal Medicine (2004)
Medical SchoolHarvard Medical School (2002)

Research Interests

Animal Models of Bariatric Surgery
Bariatric Surgery
Diabetes
Obesity

Publications

Featured
Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action.

Aguirre V, Werner ED, Giraud J, Lee YH, Shoelson SE, White MF. , Journal of Biological Chemistry , January 2002; (277(2)):1531-1537

Featured
Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways.

Rui L, Aguirre V, Kim JK, Shulman GI, Lee A, Corbould A, Dunaif A, White MF. , Journal of Clinical Investigation , January 2001; (107(2)):181-189

Featured
The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307).

Aguirre V, Uchida T, Yenush L, Davis R, White MF. , Journal of Biological Chemistry , March 2000; (275(12)):9047-9054

An endoluminal sleeve induces substantial weight loss and normalizes glucose homeostasis in rats with diet-induced obesity.

Aguirre V, Stylopoulos N, Davis P, Grinbaum R, Kaplan L , Obesity , December 2008; (16(12)):2585-2592

Expansion and contraction: treating diabetes with bariatric surgery.

Goldfine AB, Shoelson SE, Aguirre V , Nature Medicine , June 2009; (15(6)):616-617

Mechanisms of bariatric surgery and implications for the development of endoluminal therapies for obesity.

Stylopoulos N and Aguirre V , Gastrointestinal Endoscopy , June 2009; (ePub)

Honors/Awards

Medical Scientist Training Program

Harvard Medical School