Bing Li, PhD

Assistant Professor
Endowed Title: Deborah and W.A. "Tex" Moncrief Jr. Scholar in Medical Research 2008-2012
Molecular Biology
Graduate Program: Genetics and Development

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-1668
Office Fax: 214-648-1488

bing4.li@utsouthwestern.edu

Education

Graduate SchoolPennsylvania State University Main Campus, Biochemistry (2002)
Graduate SchoolPennsylvania State University Main Campus, Molecular Biology (1997)
UndergraduateBeijing Agricultural University - China, Microbiology (1994)

Research Interests

Cancer
Chromatin Biology
Epigenetic Transcription Regulation
Genomics and Proteomics
Non-coding RNA

Publications

Featured
Combined action of PHD and Chromo domains directs the Rpd3S HDAC to transcribed chromatin.

Bing Li, Madelaine Gogol, Mike Carey, Daeyoup Lee, Chris Seidel and Jerry Workman , Science , 2007; (316):1050-1054

Featured
Infrequently transcribed long genes depend on the Set2/Rpd3S pathway for accurate transcription

Bing Li, Madelaine Gogol, Mike Carey, Samantha Pattenden, Chris Seidel and Jerry Workman , Genes& Development , 2007; (21/11):1422-30

Featured
The role of chromatin during transcription

Bing Li, Michael Carey and Jerry Workman , Cell , 2007; (128/4):707-719

Featured
Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription

M. Carrozza, Bing Li, Laurence Florens, Tamaki Suganuma, Selene Swanson, Kenneth Lee,Wei-Jong Shia, Scott Anderson, John Yates, Michael Washburn and Jerry Workman , Cell , 2005; (123/4):581-592

Featured
Preferential occupancy of histone variant H2AZ at inactive promoters influence local histone modifications and chromatin remodeling

Bing Li, Samantha Pattenden, Daeyoup Lee, Jose Gutierrez, Jie Chen, Chris Seidel, Jennifer Gerton and Jerry Workman , Proc. Natl. Acad. Sci. USA , 2005; (102/51):18385-18390

Heterochromatin Protein 1a stimulates histone H3 lysine 36 demethylation by the Drosophila KDM4A demethylase

Chia-Hui Lin, Bing Li, Selene Swanson, Ying Zhang, Laurence Florens, Michael P. Washburn, Susan M. Abmayr and Jerry L. Workman , Molecular Cell , November 2008; (32(5)):696-706

Histone H3 lysine 36 di-methylation (H3K36me2) is sufficient to recruit the Rpd3S histone deacetylase complex and to repress spurious transcription

Bing Li, Jessica Jackson, Matthew D. Simon, Brian Fleharty, Madelaine Gogol, Chris Seidel, Jerry L. Workman and Ali Shilatifard , J. Biol. Chem. , 2009;

Combined action of PHD and Chromo domains directs the Rpd3S HDAC to transcribed chromatin.

Bing Li, Madelaine Gogol, Mike Carey, Daeyoup Lee, Chris Seidel and Jerry Workman , Science , 2007; (316):1050-1054

Infrequently transcribed long genes depend on the Set2/Rpd3S pathway for accurate transcription

Bing Li, Madelaine Gogol, Mike Carey, Samantha Pattenden, Chris Seidel and Jerry Workman , Genes& Development , 2007; (21/11):1422-30

MSL Complex Is Attracted to Genes Marked by H3K36 Trimethylation Using a Sequence-Independent Mechanism

Erica Larschan, Artyom A. Alekseyenko, Andrey A. Gortchakov, Shouyong Peng, Bing Li, Pok Yang, Jerry L. Workman, Peter J. Park, and Mitzi I. Kuroda , Molecular Cell , 2007; (28/1):121-133

Honors/Awards

the Basil O’Connor Scholar Research Award

March of Dimes Foundation (2011)

W.A. "Tex" Moncrief, Jr. Scholar in Medical Research

UT Southwestern Endowed Scholar (2008)

Braddock Graduate Fellowship

Department of Biochemistry and Molecular Biology, Penn State University (2000)

Paul Berg Prize in Molecular Biology

Department of Biochemistry and Molecular Biology, Penn State University (1999)