Yihong Wan, PhD

Assistant Professor
Endowed Title: Virginia Murchison Linthicum Scholar in Medical Research 2008-2012
Pharmacology
Graduate Program: Cancer Biology
Integrative Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-645-6062
Office Fax: 214-645-6166

yihong.wan@utsouthwestern.edu

Education

Graduate SchoolUniversity of Colorado at Denver, Molecular Biology (2001)
Graduate SchoolSouthern Illinois University-Carbondale, Chemistry (1996)
UndergraduateNankai University, Biochemistry (1994)

Research Interests

Bone Homeostasis and Osteoclasts - Osteoporosis & Bone Metastasis of Cancers
Lactation in Neonatal Health and Breast Cancer - Metabolism and Inflammation
Transcriptional Regulation by Nuclear receptors

Publications

Featured
Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor ?

Wei W, Dutchak PA, Wang X, Ding X, Wang X, Bookout AL, Goetz R, Mohammadi M, Gerard RD, Dechow PC, Mangelsdorf DJ, Kliewer SA, Wan Y, Proceedings of the National Academy of Sciences of the United States of America, 2012 Feb;

Biphasic and dosage-dependent regulation of osteoclastogenesis by ß-catenin.

Wei W, Zeve D, Suh JM, Wang X, Du Y, Zerwekh JE, Dechow PC, Graff JM, Wan Y, Molecular and cellular biology, 2011 Dec; 31 (23):4706-19

Osteoclast progenitors reside in the peroxisome proliferator-activated receptor ?-expressing bone marrow cell population.

Wei W, Zeve D, Wang X, Du Y, Tang W, Dechow PC, Graff JM, Wan Y, Molecular and cellular biology, 2011 Dec; 31 (23):4692-705

Thiazolidinediones on PPAR?: The Roles in Bone Remodeling.

Wei W, Wan Y, PPAR research, 2011 ; 2011:867180

PGC1beta mediates PPARgamma activation of osteoclastogenesis and rosiglitazone-induced bone loss.

Wei W, Wang X, Yang M, Smith LC, Dechow PC, Sonoda J, Evans RM, Wan Y, Cell metabolism, 2010 Jun; 11 (6):503-16

Rosiglitazone activation of PPARgamma suppresses fractalkine signaling.

Wan Y, Evans RM, Journal of molecular endocrinology, 2010 Feb; 44 (2):135-42

PPAR? in bone homeostasis.

Wan Y, Trends in endocrinology and metabolism: TEM, 2010 Dec; 21 (12):722-8

PPAR-gamma regulates osteoclastogenesis in mice.

Wan Y, Chong LW, Evans RM, Nature medicine, 2007 Dec; 13 (12):1496-503

Maternal PPAR gamma protects nursing neonates by suppressing the production of inflammatory milk.

Wan Y, Saghatelian A, Chong LW, Zhang CL, Cravatt BF, Evans RM, Genes & development, 2007 Aug; 21 (15):1895-908

Honors/Awards

Basil O’Connor Starter Scholar Research Award

March of Dimes (2010)

Individual Investigator Award

Cancer Prevention and Research Institute of Texas (2010)

John Haddad Young Investigator Award

American Society for Bone and Mineral Research (2009)

Virginia Murchison Linthicum Scholar in Medical Research

UTSW Endowed Scholar (2008)

BD Research Grant Award

Becton Dickinson Biosciences (2007)

Professional Associations/Affiliations

American Society for Bone and Mineral Research

European Calcified Tissue Society

The Endocrine Society