Kiyoshi Ariizumi, PhD

Associate Professor
Dermatology
Graduate Program: Immunology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-633-1835
Office Fax: 214-648-5554

kiyoshi.ariizumi@utsouthwestern.edu

Biography

Dr. Ariizumi has served on the faculty of UT Southwestern Medical Center, Department of Dermatology since 1992. His research interests include:

  • Immune evasion by melanoma
  • Role of C-type lectin receptors in innate immunity
  • Negative regulation of T cel-mediated immunity.

Education

Graduate SchoolUniversity of Tokyo - Japan (1985)

Research Interests

Immune evasion by melanoma
Negative regulation of T cell-mediated immunity
Role of C-type lectin receptors in innate immunity

Publications

Featured
DC-HIL is a negative regulator of T cell activation.

Chung J-S, Sato K, Dougherty I, Cruz PD Jr, Ariizumi K. , Blood , Spring 2007; (109):4320-4327

Featured
Cloning of a second dendritic Cell-associated C-type lectin (Dectin-2) and its alternatively spliced isoforms.

Ariizumi K, Shen G-L, Shikano S, Ritter RIII, Zukas P, Edelbaum D, Morita A, Takashima A. , J Biol Chem , 2000; (275):11957-11963

Selective expression of vacuolar H+-ATPase subunit d2 by particular subsets of dendritc cells among leukocytes

Sato K, Shikano S, Xia G, Takao J, Cruz PD Jr, Xie X-S, Ariizumi K , Mol. Immunol. , March 2006; (43):1443-1453

Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor  chain to induce innate immune responses.

Sato K, Yang X-L, Yudate T, Chung J-S, Wu J, Luby-Phelps K, Kimberly RP, Underhill D, Cruz PD Jr., and Ariizumi K , J. Biol. Chem. , December 2006; (281):38854-38866

Sézary syndrome cells overexpress syndecan-4 bearing distinct heparan sulfate moieties that suppress T-cell activation by binding DC-HIL and trapping TGF-beta on the cell surface.

Chung JS, Shiue LH, Duvic M, Pandya A, Cruz PD, Ariizumi K, Blood, 2011 Mar; 117 (12):3382-90

Inhibition of T-cell activation by syndecan-4 is mediated by CD148 through protein tyrosine phosphatase activity.

Chung JS, Cruz PD, Ariizumi K, European journal of immunology, 2011 Jun; 41 (6):1794-9

DC-HIL/glycoprotein Nmb promotes growth of melanoma in mice by inhibiting the activation of tumor-reactive T cells.

Tomihari M, Chung JS, Akiyoshi H, Cruz PD, Ariizumi K, Cancer research, 2010 Jul; 70 (14):5778-87

Depleting syndecan-4+ T lymphocytes using toxin-bearing dendritic cell-associated heparan sulfate proteoglycan-dependent integrin ligand: a new opportunity for treating activated T cell-driven disease.

Akiyoshi H, Chung JS, Tomihari M, Cruz PD, Ariizumi K, Journal of immunology (Baltimore, Md. : 1950), 2010 Apr; 184 (7):3554-61

Binding of DC-HIL to dermatophytic fungi induces tyrosine phosphorylation and potentiates antigen presenting cell function.

Chung JS, Yudate T, Tomihari M, Akiyoshi H, Cruz PD, Ariizumi K, Journal of immunology (Baltimore, Md. : 1950), 2009 Oct; 183 (8):5190-8

The DC-HIL/syndecan-4 pathway inhibits human allogeneic T-cell responses.

Chung JS, Bonkobara M, Tomihari M, Cruz PD, Ariizumi K, European journal of immunology, 2009 Apr; 39 (4):965-74

Honors/Awards

Research career Development Award

Awarded by the Dermatology Foundation (1994)

Henry Christian Memorial Award

Awarded by the American Federation for Clinical Research (1993)

Professional Associations/Affiliations

American Association of Immunologists

Society for Investigative Dermatology