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Joseph Albanesi, PhD
Molecular Biophysics
Contact Information
UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390
Office Phone: 214-645-6119
Office Fax: 214-645-6124
Biography
I received my undergraduate degree from Dartmouth College in 1974 and a Ph.D. in biochemistry from Duke University in 1980. As a result of my postdoctoral research at the National Institutes of Health (Bethesda, MD), I became interested in the mechanism of secretory vesicle biogenesis and trafficking. Since joining the UT Southwestern faculty in 1987, I have pursued several topics related to membrane vesiculation. At present, we are examining the functions and regulations of dynamin, a large (100kDa) GTPase that severs the necks of nascent vesicles, thereby releasing them from their parent membranes. Dynamin activity is required for receptor-mediated endocytosis and synaptic vesicle recycling, and may also be essential for Golgi budding. In previous studies we determined the physical and kinetic properties of dynamin, and established that its function is regulated in cells by binding to specific phosphoinositide lipids. As part of this work, we cloned and characterized a novel family of phosphoinositide kinases that may have key roles in vesicle biogenesis from the Golgi apparatus. We are continuing our efforts to understand how proteins and lipids cooperate to overcome energetic barriers against membrane fusion and fission.
Education
| Graduate School | Duke University (1980) |
Research Interests
Publications
Garbers DL, Chrisman TD, Wiegn P, Katafuchi T, Albanesi JP, Bielinski V, Barylko B, Redfield MM, Burnett JC Jr. , Trends Endocrinol Metab. , August 2006; (17(6)):251-258
Wang YJ, Wang J, Sun HQ, Martinez M, Sun YX, Macia E, Kirchhausen T, Albanesi JP, Roth MG, Yin HL. , Cell , August 2003; (114(3)):299-310
Wei YJ., Sun HQ., Yamamoto M., Wlodarski P., Kunii K., Martinez M., Barylko B., Albanesi JP., Yin HL. , J Biol Chem , November 2002; (277(48)):46586-93
Barylko B, Gerber SH, Binns DD, Grichine N, Khvotchev M, Sudhof TC, Albanesi JP. , J Biol Chem , March 2001; (276(11)):7705-7708
Achiriloaie, M., Barylko, B., and Albanesi, J.P. , Mol. Cell Biol. , February 1999; (19):1410-1415
Jung, G., Wang, J., Wlodarski, P., Barylko, B., Binns, DD., Shu, H., Yin, HL., Albanesi, JP. , Biochem J. , January 2008; (409):501-509
Rodgers MJ., Albanesi JP., Phillips MA. , Eukaryot Cell , July 2007; (6(7)):1108-18
Barylko B., Wlodarski P., Binns DD., Gerber SH., Earnest S., Sudhof TC., Grichine N., Albanesi JP. , J Biol Chem , November 2002; (277(46)):44366-75
Bagatolli, L.A., Binns, D.D., Jameson, D.M., and Albanesi, J.P. , J. Protein Chem. , 2002; (21):383-391
Markin, V.S. and Albanesi, J.P. , Biophys. J. , 2002; (82):693-712
Honors/Awards
(2006)
Established Investigator Award, 1989-1994