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John Abrams, PhD
Genetics and Development
Contact Information
UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390
Office Phone: 214-648-9226
Office Fax: 214-648-8694
Biography
John Abrams graduated from Cornell University in 1982 and received a National Science Foundation Fellowship for graduate work at Stanford University the following year. Under the mentorship of Dr. Robert Schimke, he analyzed the regulation, amplification and mutagenesis of transfected genes, receiving a PhD. in 1989. Later that year, Dr. Abrams moved to MIT as an American Cancer Society fellow, where he joined the lab of Hermann Steller and launched molecular studies on programmed cell death. Using the Drosophila model, he uncovered the first global cell death defective mutation in this animal and later he identified the gene ’reaper’ as the relevant locus encoding the predicted apoptotic function. Small molecules that simulate the activity encoded by this gene are now attracting widespread attention as promising anti-cancer drugs. In 1994, Dr. Abrams joined the faculty at UT Southwestern, where he continues research on the molecular physiology of cell death. His lab has identified additional apoptosis genes and, in ongoing efforts, his group continues to use genetic systems to explore cell death pathways and their intersection with p53, a tumor suppressor gene that is commonly mutated in human cancers. In 2001, Dr. Abrams received an ACS Research Scholar award. He is currently a Professor in the department of Cell Biology and Chair of the Genetics and Development graduate program.
Education
| Graduate School | Stanford University (1989) |
| Undergraduate | Cornell University (1982) |
Research Interests
Publications
Chew, S.,Chen, P., Link, N., Galindo, K., Pogue, K. and Abrams, J.M. , Nature , July 2009; (460):123-127
Chew, S.,Chen, P., Link, N., Galindo, K., Pogue, K. and Abrams, J.M. , Nature , July 2009; (460):123-7
Link, N., Chen, P., Lu, WJ, Pogue, K., Chuong, A., Mata, M., Checketts, J., Abrams, J.M , J. Cell Biol , August 2007; (4 (178)):567-74
Akdemir, F., Christich, A., Sogame, N., Chapo, J., and Abrams, J.M , Oncogene , February 2007;
Chew, S., Akdemir, F.,Chen, P., Lu, W., Mills, K.,Daish, T.,Kumar, S.,Rodriguez,, A. and Abrams, J.M , Developmental Cell , December 2004; (Volume 7):897-907
Sogame N, Kim M, Abrams JM, Proceedings of the National Academy of Sciences of the United States of America, 2003 Apr; 100 (8):4696-701
Brodsky, M, H. Nordstrom, W, Tsang, G., Kwan, E., Rubin, G.M. and Abrams, J.M. , Cell , 2000; (101):103-113
Rodriguez, A., Oliver, H., Zou, H., Chen, P., Wang, X. and Abrams, J.M. , Nature Cell Biology , 1999; (1):272-279
Lu, WJ Chapo, J. Roig, I. Abrams, J.M. , Science , June 2010; (328):1278-81
Akdemir, F., Farkas, R., Chen, P., Juhasz, G., Medvedova, L., Sass, M., Wang, L., Wang, X., Chittaranian, S., Gorski, SM., Rodriguez, A., Abrams, JM , Development , 2006; (133):1457-65
Related Links
Honors/Awards
Senior Scholar (2011)
Research Scholar (2001)
Postdoctoral Fellowship (1992)
Postdoctoral Fellowsip (1989)
Graduate Fellowship (1983)