Lupus erythematosus is an autoimmune disease that afflicts several organs in the body, including the skin. Because the pathogenesis of cutaneous lupus erythematosus is not fully elucidated, using a mouse model that mimics cutaneous lupus erythematosus in humans would be essential to furthering the knowledge base of this disease. I will be investigating the MRL/lpr mouse model and devising other mouse models involving autoantibodies. From these models, we hope to elucidate the relative contributions of genetics and the presence of autoantibodies to the pathogenesis of cutaneous lupus erythematosus. In addition, I will be investigating various signaling pathways from skin biopsies obtained from patients with different forms of cutaneous lupus erythematosus, including acute lupus erythematosus, subacute cutaneous lupus erythematosus, and discoid lupus erythematosus. I will be actively recruiting patients who will be interested in participating in this study. Such pathways could present novel targets for therapeutics to be designed in the future for cutaneous lupus.
RESEARCH INTERESTS
Cutaneous Lupus Erythematosus
Cutaneous Sarcoidosis
RECENT PUBLICATIONS
Chong, BF, Mohan C, "Targeting the CXCR4/CXCL12 axis in systemic lupus erythematosus" Expert Opin Ther Targets, 13(10):1147-53, October 2009
Chong, BF, Wong, HK, "Treatment of psoriasis with etanercept in patient with history of primary B-cell lymphoma" Clin Exp Dermatol, 34(5):e11-3, July 2009
Chong BF, Wilson AJ, Gibson HM, Hafner MS, Luo Y, Hedgcock C, Wong HK, "Immune function abnormalities in peripheral blood mononuclear cell cytokine expression differentiates stages of cutaneous T-cell lymphoma/mycosis fungoides" Clin Cancer Res, 14(3):646-53, February 2008
Chong B, Nydorf ED, Lim HW, "Concomitant morphea and pigmented purpuric dermatosis in a 62-year-old woman" J Eur Acad Dermatol Venereol, 21(6):826-28, July 2007
Chong, BF, Wong, HK, "Immunobiologics in the treatment of psoriasis" Clin Immunol, 123(2):129-38, May 2007
SIGNIFICANT PUBLICATIONS
Chong BF, Wong HK, "Immunobiologics in the treatment of psoriasis" Clin Immunol, 123:129-138, May 2007
Clark RA, Chong BF, Mirchandani N, Yamanaka KI, Murphy GF, Dowgiert RK, Kupper TS., "A novel method for the isolation of skin resident T cells from normal and diseased human skin." J Invest Dermatol, 126:1059-1070, May 2006
Clark RA, Chong B, Mirchandani N, Brinster NK, Yamanaka KI, Dowgiert RK, Kupper TS., "The vast majority of CLA+ T cells are resident in normal skin." J Immunol, 176:4431-4439, April 2006
Chong BF, Murphy J, Kupper TS, Fuhlbrigge RC., "E-selectin, TARC/CCL17, and ICAM-1 are constitutively co-expressed in dermal microvessels: a foundation for a cutaneous immunosurveillance system." J Immunol, 172:1575-1581, February 2004
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