Despite its importance in maintaining life, energy homeostasis is often affected in patients with psychiatric disorders (e.g., depression and anorexia nervosa). My laboratory is thus interested in understanding the molecular and neuroanatomic basis that links metabolism and emotion. We utilize combinations of methods including tract-tracing, viral-mediated gene transfer, metabolic and behavioral assay, qPCR, and the use of genetically-engineered mice. To complement and extend the mouse studies, we analyze the expression of relevant genes in postmortem human brains.
RESEARCH INTERESTS
Limbic circuitries that link emotion and energy homeostasis
Brain reward pathways
RECENT PUBLICATIONS
Kishi T, Tsumori T, Yokota S, Yasui Y., "Topographical projection from the hippocampal formation to the amygdala: a combined anterograde and retrograde tracing study in the rat." J Comp Neurol, 496(3):349-368, 2006
Heisler LK, Jobst EE, Sutton GM, Zhou L, Borok E, Thornton-Jones Z, Liu HY, Zigman JM, Balthasar N, Kishi T, Lee CE, Aschkenasi CJ, Zhang CY, Yu J, Boss O, Mountjoy KG, Clifton PG, Lowell BB, Friedman JM, Horvath T, Butler AA, Elmquist JK, Cowley MA., "Serotonin reciprocally regulates melanocortin neurons to modulate food intake." Neuron, 51(2):239-429., 2006
Balthasar N, Dalgaard LT, Lee CE, Yu J, Funahashi H, Williams T, Ferreira M, Tang V, McGovern RA, Kenny CD, Christiansen LM, Edelstein E, Choi B, Boss O, Aschkenasi C, Zhang CY, Mountjoy K, Kishi T, Elmquist JK, Lowell BB., "Divergence of melanocortin pathways in the control of food intake and energy expenditure." Cell, 123(3):493-505, 2005
Kishi T, Aschkenasi CJ, Choi BJ, Lopez ME, Lee CE, Liu H, Hollenberg AN, Friedman JM, Elmquist JK., "Neuropeptide Y Y1 receptor mRNA in rodent brain: distribution and colocalization with melanocortin-4 receptor." J Comp Neurol, 482(3):217-243, 2005
Kishi T, Elmquist JK, "Body weight is regulated by the brain: a link between feeding and emotion." Mol Psychiatry, 10(2):132-146., 2005
SIGNIFICANT PUBLICATIONS
Liu H, Kishi T, Roseberry AG, Cai X, Lee CE, Montez JM, Friedman JM, Elmquist JK., "Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter." J Neurosci, 23(18):7143-7154., 2003
Kishi T, Aschkenasi CJ, Lee CE, Mountjoy KG, Saper CB, Elmquist JK., "Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat." J Comp Neurol, 457(3):213-235, 2003
Kishi T, Tsumori T, Ono K, Yokota S, Ishino H, Yasui Y., "Topographical organization of projections from the subiculum to the hypothalamus in the rat." J Comp Neurol, 419(2):205-222, 2000
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