One of the most exciting strengths of nuclear magnetic resonance spectroscopy (MRS) is its ability to measure biochemical concentrations in human body noninvasively. Despite the progress achieved during the past decades, precise and reliable measurements of several clinically-important, low abundant biochemicals still remain as challenges. A primary reason for this is that the spins of many biochemicals are scalar coupled, and consequently the spectral analysis is complicated. Current researches focus on development of spectral editing techniques for detection of GABA, glutamine, glycine, NAAG, lactate, glutathione, serine, etc. at both 7T and 3T.
RESEARCH INTERESTS
1H and 13C MRS
Application of MRS to neurodegenerative and cancer diseases
RF pulse and RF coil design
Density matrix simulation
RECENT PUBLICATIONS
Choi C, Bhardwaj PP, Seres P, Kalra S, Tibbo PG, Coupland NJ, "Measurement of Glycine in Human Brain by Triple Refocusing 1H-MRS In Vivo at 3.0 T" Magnetic Resonance in Medicine, 59:59-64, 2008
Choi C, Coupland NJ, Kalra S, Bhardwaj PP, Malykhin N, Allen PS, "Proton Spectral Editing for discrimination of lactate and threonine 1.31 ppm resonances in human brain in vivo" Magnetic Resonance in Medicine, 56:660-665, 2006
Choi C, Coupland NJ, Bhardwaj PP, Malykhin N, Gheorghiu D, Allen PS, "Measurement of Brain Glutamate and Glutamine by Spectrally-Selective Refocusing at 3 Tesla" Magnetic Resonance in Medicine, 55:997-1005, 2006
Choi C, Ogilvie CJ, Malykhin N, Ngo JTV, Hartfeil MAW, Coupland NJ, "Detection of the myo-inositol 4.06 ppm resonance by selective J rewinding: Application to human prefrontal cortex in vivo" Magnetic Resonance in Medicine, 54:1536-1540, 2005
Choi C, Coupland NJ, Hanstock CC, Ogilvie CJ, Higgins ACM, Gheorghiu D, Allen PS, "Brain GABA measurements by proton double quantum filtering with selective J rewinding" Magnetic Resonance in Medicine, 54:272-279, 2005
SIGNIFICANT PUBLICATIONS
Choi C, Bhardwaj PP, Kalra S, Casault CA, Yasmin US, Allen PS, Coupland NJ, "Measurement of GABA and contaminants in grey and white matter in human brain in vivo" Magnetic Resonance in Medicine, 58:27-33, 2007
Choi C, Coupland NJ, Bhardwaj PP, Kalra S, Casault CA, Reid K, Allen PS, "T2 measurement and quantification of glutamate in human brain in vivo" Magnetic Resonance in Medicine, 56:971-977, 2006
Choi C, Pintar MM, "Observation of CH3 tunneling manifold by level-crossing NMR" Physical Review Letters, 76:527-530, 1996
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