Our research is focused on determining the mechanistic basis for the development of type II diabetes as it relates to cellular dysfunction in adipocytes, beta cells and hepatocytes. We aim to develop novel therapeutic approaches to improve insulin sensitivity
RESEARCH INTERESTS
Adipocytes
Beta Cells
Angiogenesis
Breast Cancer
Intracellular Protein Trafficking
RECENT PUBLICATIONS
Wang, Z.V., Mu, J., Schraw, T.D., Gautron, L., Elmquist, J.K., Zhang, B.B., Brownlee, M., P.E. SCHERER, "PANIC-ATTAC, a mouse model for inducible and reversible Beta cell ablation" Diabetes, in press 2008
Schraw, T.D., Wang, Z.V., Halberg, N., Hawkins, M. and P.E. SCHERER, "Plasma adiponectin complexes have distinct biochemical characteristics" Endocrinology, 149(5):2270-2282, 2008
Kim, J-Y., van del Wall, E., Laplante, M., Azzara, A., Trujillo, M.E. Hofmann, S.M., Schraw, T.D. Durand, J.L., Li, H., Li, G., Jelicks, L.A., Mehler, M.F., Hui, D.Y., Deshaies, Y., Schulman, G.I., Schwartz, G.J. and P.E. SCHERER, "Obesity-associated improvements in metabolic profile in mice: Rescue of the diabetic phenotype through expansion of adipose tissue mass" J Clin Invest, 117(9):2621-2637, 2007
Wang, Z.V., Schraw, T.D., Kim, J-Y., Khan, T., Rajala, M.W., Follenzi, A. and P.E. SCHERER, "Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention" Mol Cell Biol, (10):3716-3731, 2007
SIGNIFICANT PUBLICATIONS
Halberg, N., Wernstedt-Asterholm, I., and P.E. SCHERER, "The adipocyte as an endocrine cell" Endocrinology and Metabolism Clinics of North America, in press 2008
Wang, Z.V., P.E. SCHERER, "ADIPONECTIN, CARDIOVASCULAR FUNCTION AND HYPERTENSION" Hypertension, 75(3):1066-1078, 2008
Wernstedt-Asterholm, I., Halberg, N. and P.E. SCHERER, "Mouse models of lipodystrophy - Key reagents for the understanding of the metabolic syndrome" Drug Discovery Today: Diease Models, in press 2007
Desruisseaux, M.S., Nagajyothi, Trujillo, M.E., Tanowitz, H.B., and P.E. SCHERER, "Adipocyte, adipose tissue, and infectious diease" Infect Immun, 75(3):1066-1078, 2007
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