Dr. Schwarz’ translational research interests focus on experimental combination therapy for pancreatic, hepatobiliary, and gastric cancer. His laboratory-based research has explored the use of antiangiogenic therapy alone or in combination with conventional cytotoxic chemotherapy in vivo. The strategy of combining therapeutic agents that address various targets supporting the cancer progression has led to significant delays of experimental cancer growth, with extension of survival. Currently, the laboratory focuses on mechanisms of cancer cell adhesion, migration, and invasion, that may represent promising targets to enhance anticancer effects in combination therapy with an antiangiogenic component.
RESEARCH INTERESTS
mutimodality therapy of pancreatic, hepatobiliary and upper GI cancer
clinical outcomes after major visceral resections
antiangiogenic cancer therapy
combination therapy of experimental pancreatic cancer
integrin and fibronectin-related targets of antiangiogenic cancer therapy
RECENT PUBLICATIONS
Schwarz, R.E., Smith, D.D., "Lymph node dissection impact on staging and survival of extrahepatic cholangiocarcinomas, based on U.S. population data." J. Gastrointest. Surg., 11(2):158-65, February 2007
Konduri, S., Schwarz, R.E., "Estrogen receptor beta / alpha ratio predicts pancreatic cancer cell response to estrogens and phytoestrogens." J. Surg. Res., 140(1):55-66, June 2007
Schwarz, R.E., "Factors influencing change of preoperative treatment intent in patients with gastrointestinal cancer." World J. Surg. Oncol., 5(1):32, March 2007
Verma, V., Schwarz, R.E., "Factors influencing perioperative blood transfusions in patients with gastrointestinal cancer." J. Surg. Res., 141 (1):97-104, July 2007
Schwarz, R.E., Smith, D.D., "Clinical impact of lymphadenectomy extent in resectable esophageal cancer." J. Gastrointest. Surgery, (in press) 2007
SIGNIFICANT PUBLICATIONS
Schwarz, R.E., Smith, D.D., "Clinical impact of lymphadenectomy extent in resectable gastric cancer of advanced stage." Ann. Surg. Oncol., 14(2):317-328, February 2007
Schwarz, R.E., "Visceral organ resections combined with synchronous major hepatectomy: examples of safety and feasibility." HPB J. Internat. Hepato Pancreato Biliary Assoc., 5(1):27-32, 2003
Schwarz, R.E., Smith, D.D., Keny, H., Ikle, D.N., Shibata, S.I., Chu, D.Z.J., Pezner, R.D., "The impact of intraoperative radiation on postoperative and disease-specific outcome after pancreatoduodenectomy for adenocarcinoma: a propensity score analysis." Am. J. Clin. Oncol., 26 (1):16-21, 2003
Schwarz, R.E., Zagala-Nevarez, K., "Recurrence patterns after radical gastrectomy for gastric cancer: prognostic factors and implications for postoperative adjuvant therapy." Ann. Surg. Oncol., 9(4):394-400, 2002
Schwarz, R.E., Harrison, L.E., Conlon, K.C., Klimstra, D.S., Brennan, M.F., "The impact of splenectomy on outcome after resection of pancreatic adenocarcinoma." J. Am. Coll. Surg., 188:516-521, 1999
Point and right click (click and hold for Mac users) your mouse onand select "Save this link (or target) as..." option to save the file to your local computer.
and select "Save this link (or target) as..." option to save the file to your local computer.