My research is focused on understanding T cell mediated autoimmunity leading to the human autoimmune disease Multiple Sclerosis (MS) and the rodent model of Experimental Autoimmune Encephalomyelitis. Our efforts are aimed at understanding the signals that T cells receive to become functional and finding ways to manipulate those signals to prevent autoimmunity and to establish self-tolerance. We are currently studying the Notch signaling pathway and its function in T cell activation.
RESEARCH INTERESTS
Neuroimmunology
Autoimmunity
T cell activation
Notch signaling
Anergy
RECENT PUBLICATIONS
10. Eagar TN, Tang Q, Wolfe M, He Y, Pear WS, Bluestone JA, "Notch 1 signaling regulates peripheral T cell activation." Immunity, 20:407-15, April 2004
11. Eagar TN, Turley DM, Padilla J, Karandikar NJ, Tan L, Bluestone JA, Miller SD, "CTLA-4 regulates expansion and differentiation of Th1 cells following induction of peripheral T cell tolerance." Journal of Immunology, 172:7442-7450., Summer 2004
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