Pharmacokinetics and pharmacodynamics of antituberculosis agents
Pharmacokinetics and pharmacodynamics of antifungal agents
PK-PD and mathematical modeling to translate from disease models to human therapy
Use of pharmacology to probe the pathogenesis of tuberculosis
RECENT PUBLICATIONS
Gumbo T, Louie A, Liu W, Brown D, Ambrose P, Bhavnani SM, Drusano GL., "Isoniazid bactericidal activity and resistance emergence: Integrating pharmacodynamics and pharmacogenomics to predict efficacy in different ethnic populations." Antimicrobial Agents and Chemotherapy, 51 (7):2329-2336, July 2007
Gumbo T, Louie A, Liu W, Ambrose PG, Bhavnani S, Brown D, Drusano GL, "Cessation of isoniazid bactericidal activity is due to emergence of resistance, not depletion of log-phase growth Mycobacterium tuberculosis." Journal of Infectious Diseases, 195:194-201, 2007
Gumbo T, Louie A, Deziel MR, Parsons LM, Salfinger M, Drusano GL., "Selection of a Moxifloxacin Dose that Suppresses Mycobacterium tuberculosis Resistance Using In Vitro Pharmacodynamic Infection Model and Mathematical Modeling" Journal of Infectious Diseases, 190:1642-1651, November 2004
Gumbo T, Drusano GL, Liu W, Ma L, Deziel MR, Drusano MF, Louie A., "Anidulafungin Pharmacokinetics and Microbial Response in Neutropenic Mice With Disseminated Candidiasis" Antimicrobial Agents and Chemotherapy, 50:3695-3700, November 2006
Gumbo T, Drusano GL, Liu W, Fregeau C, Hsu V, Louie A., "Once A Week Micafungin Therapy Is As Effective As Daily Therapy In Persistently Neutropenic Mice With Disseminated Candidiasis." Antimicrobial Agents and Chemotherapy, 51:968-974, March 2007
SIGNIFICANT PUBLICATIONS
Gumbo, T, "Integrating pharmacokinetics, pharmacodynamics and pharmacogenomics to predict outcomes in antibacterial therapy" Current Opinion in Drug Discovery and Development, 11 (1):32-42, January 2008
Ambrose PG, Bhavnani SM, Rubino CM, Louie A, Gumbo T, Forrest A, Drusano GL., "Pharmacokinetics-Pharmacodynamics of antimicrobial therapy: Its not just mice anymore" Clinical Infectious Diseases, 44:79-86, January 2007
Gumbo T, "Impact of pharmacodynamics and pharmacokinetics on echinocandin dosing strategies" Current Opinion in Infectious Diseases, 20 (6):587-591, December 2007
Gumbo T, Isada CM, Hall G, Karafa M, Gordon SM., "Candida glabrata fungemia: Clinical features of 139 patients" MEDICINE (Baltimore), 78:220-227, 1999
Gumbo T, Sarbah S, Gangaidzo I, Ortega Y, Sterling CR, Carville A, Tzipori S, Wiest PM, "Intestinal parasites in patients with diarrhea and human immunodeficiency virus in Zimbabwe" AIDS, 13:819-821, 1999
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