My research is focused on two main questions: 1) How have population history and natural selection have interacted to produce patterns of genetic variation?, and 2) How can information about population history and natural selection be used in the dissection of genotype-phenotype correlations? My lab investigates these questions using a combination of empirical, theoretical, and computational methods to analyze patterns of diversity in populations around the world. Over the years, we have worked on many different genes in many different organisms, including bears, viruses, and even chimpanzees; however, our current emphasis is on patterns of variability in genes controlling taste perception in humans.
RESEARCH INTERESTS
Evolution
Genetics
Population Genetics
Taste
Taste Sensitivity
RECENT PUBLICATIONS
Wooding, S., Bufe, B., Grassi, C., Howard, M.T., Stone, A.C., Vazquez, M., Dunn, D.M., Meyerhof, W., Weiss, R.B., Bamshad, M.J., "Independent evolution of bitter-taste sensitivity in humans and chimpanzees." Nature, 440:930-934, 2006
Wooding, S., Stone, A. C., Dunn, D. M., Jorde, L. B., Weiss, R. K., Ahuja, S., Bamshad, M. J., "Contrasting effects of natural selection on human and chimpanzee CC chemokine receptor 5." American Journal of Human Genetics, 76:291-301, 2005
Wooding, S., Kim, U.-k., Bamshad, M. J., Larsen, J., Jorde, L. B., Drayna, D., "Natural selection and molecular evolution in PTC, a bitter taste receptor gene." American Journal of Human Genetics, 74:637-646, 2004
Bamshad, M., Wooding, S., "Signatures of natural selection in the human genome." Nature Reviews Genetics, 4:99-111, 2003
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