Our research is focused on the functional neuroanatomy of the mammalian hypothalamus. We work mainly on the regulation of body weight homeostasis, food intake and control of the autonomic nervous system.
RESEARCH INTERESTS
Central autonomic control
Neurobiology and neuroanatomy of the hypothalamus
Boby weight homeostasis
Diabetes and Glucose Homeostasis
RECENT PUBLICATIONS
Heisler, L. K., E. E. Jobst, G. Sutton, N. Balthasar, L. Zhou, E. Borok, H. Y. Liu, J. M. Zigman, T. Kishi, C. Lee, C. J. Aschkenasi, C. Zhang, J. Yu, O. Boss, K. Mountjoy, B. Lowell, J. Friedman, A. Butler, T. Horvath, J. K. Elmquist, and Michael A. Cowley, "Serotonin Reciprocally Regulates Melanocortin Neurons to Modulate Food Intake" 2006, Neuron 51:239-249
Dhillon, H., J. M. Zigman, C. Ye, C. E. Lee, N. R. A. McGovern, V. Tang, C. D. Kenny, L. M. Christiansen, R. D. White, E. Edelstein, R. Coppari, N. Balthasar, M.A. Cowley, S. C. Chua Jr., J. K. Elmquist, and B. B. Lowell, "Leptin Directly Activates SF1 Neurons in the Ventromedial Hypothalamus and this Action by Leptin is Required for Normal Body Weight Homeostasis" 2006, Neuron 49:191-203
Zigman, J.M., Y. Nakano, R. Coppari, N. Balthasar, J. N. Marcus, C. E., Lee, J. E. Jones, A. E. Deysher, A. R. Waxman, R. D. White, T.D. Williams, J. L. Lachey, R. J. Seeley, B. B. Lowell, and J. K. Elmquist, "Mice Lacking Ghrelin Receptors Resist the Development of Diet-Induced Obesity" 2005, Clinical Invest. 115:3564-3572
Balthasar, N. L., T. Dalgaard, C. E. Lee, J. Yu, H. Funahashi, T. Williams, M. Ferreira, V. Tang, R. A. McGovern, C.D. Kenny, L. M. Christiansen, E. Edelstein, B. Choi, Olivier Boss, C. Aschkenasi, C. Zhang, K. Mountjoy, T. Kishi, J. K. Elmquist, and B. B. Lowell, "Divergence of Melanocortin Pathways in Control Food Intake and Energy Expenditure" 2005, Cell 123:495-505
Hill J, K. W. Williams, C. Ye, J. Luo, N. Balthasar, R. Coppari, M. A. Cowley, L. C. Cantley, B. B. Lowell, J.K. Elmquist, "Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice" Journal of Clinical Investigation, 118:1796-1805, May 2008
SIGNIFICANT PUBLICATIONS
Marcus, J.N., C. J. Aschkenasi, R. M. Chemelli, C. B. Saper, M. Yanagisawa, and J. K. Elmquist, "Differential Expression of Orexin Receptors 1 and 2 in the Rat Brain" 2001, J. Comp. Neurol 435:6-25
Coppari, R., M. Ichinose, C. E. Lee, A. E. Pullen, C. D. Kenny, R. A. McGovern, V. Tang, S. M. Liu, T. Ludwig, S. C. Chua Jr., B. B. Lowell, and J. K. Elmquist, "The Hypothalamic Arcuate Nucleus: A Key Site for Mediating Leptin’s Effects on Glucose Homeostasis and Locomotor Activity" 2005, Cell Metabolish 1:63-72
Balthasar, N., R. Coppari, C. E. Lee, V. Tang, C. D. Kenny, R. A. McGovern, S. C. Chua Jr., J. K. Elmquist, and B. B. Lowell, "Leptin Receptor Signaling in POMC Neurons is Required for Normal Body Weight Homeostasis" 2004, Neuron 42:983-991
Kishi, T., C. J. Aschkenasi, C. E. Lee, K. G. Mountjoy, C. B. Saper, and J. K. Elmquist, "Expression of Melanocortin 4 Receptor mRNA in the Central Nervous System of the Rat" 2003, J. Comp. Neurol 457:213-235
Heisler, L. K., M. A. Cowley, L. H. Tecott, W. Fan, M. J. Low, J. L. Smart, M. Rubinstein, J. B. Tatro, H. Holstege, C. E. Lee, R. D. Cone, and J. K. Elmquist, "Activation of Central Melanocortin Pathways by Fenfluramine" 2002, Science 297:609-611
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