My main research interest is to understand the molecular mechanisms underlying primary brain tumors, specifically Gliblastoma Multiform (GBM), the most frequent and lethal of all primary brain tumors affecting the adult population. Towards this goal, my laboratory focuses on 3 main areas: (1) to develop mouse models that will faithfully recapitulate human GBM, (2) to understand how cell fate decisions are made during embryonic brain development to generate the cell type(s) which ultimately give rise to these tumors and (3) to understand the interactions of GBM tumor cells and their normal brain microenvironment.
RESEARCH INTERESTS
Stem Cell Biology
Brain Development
Malignant Transformation
Angiogenesis
Tumor Micro Environment
RECENT PUBLICATIONS
Bachoo R, Kim R, Ligon K, Maher E, Brennan C, Billings N, Chan S, Li C, Rowitch D, Wong W, DePinho R, "Molecular diversity of astrocytes with implications for neurological disorders" PNAS, 101(22):8384-8389, 2004
St-Pierre, J., Droir, S., Uldry, M., Rhee, J., Lin, J, Handshin, C., Yang, W., Bachoo,R., Spigelman,BM, "Suppression of reactive oxygen species and MPTP-induced neurodegenration by the PGC-1 transcriptional coactivator" Cell 127(2):397-408., 127 (2):397-408., October 2006
SIGNIFICANT PUBLICATIONS
Bachoo, R., Maher, E., Ligon, K., Sharpless, N., Chan, S., You, M., Tang, Y., DeFrances, J., Stover, E., Weissleder, R., Rowitch, D., Louis, D., DePinho, R., "Epidermal Growth Factor Receptor and Ink4a/Arf: Convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis." Cancer Cell, 1(3):269-277, April 2002
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