The Gao Lab combines research expertise in materials science, molecular imaging and cancer biology to establish integrated nanomedicine platforms for early detection and intervention of cancer. The underlying theme of our research is to translate key advances in materials science and nanotechnology into better clinical diagnosis and therapy of cancer.
RESEARCH INTERESTS
Cancer nanomedicine
Targeted drug delivery
Cancer molecular imaging
Polymer biomaterials
MRI molecular probes
RECENT PUBLICATIONS
Khemtong, C.; Kessinger, C.W.; Ren, J.; Bey, E.; Yang, S.G.; Guthi, J.; Boothman, D.A., Sherry, A.D.; Gao, J., "In Vivo Off Resonance Saturation Magnetic Resonance Imaging of alpha(v)beta(3)-Targeted Superparamagnetic Nanoparticles" Cancer Res., 69:1651-1658, 2009
Dong, Y.; Chin, S.F.; Blanco, E.; Bey, E.A.; Kabbani, W.; Xie, X.J.; Bornmann, W.G.; Boothman, D.A. Gao, J., "Intratumoral Delivery of beta-Lapachone via Polymer Implants for Prostate Cancer Therapy" Clin. Cancer Res., 15:131-139, 2009
Bey, E.A.; Bentle, M.S.; Reinicke, K.E.; Dong, Y.; Yang, C.R.; Girard, L.; Minna, J.D.; Bornmann, W.G.; Gao, J.; Boothman, D.A., "A Novel NQO1- and PARP-1-Mediated Cell Death Pathway Induced In Non-Small Cell Lung Cancer Cells By beta-Lapachone" Proc. Natl. Acad. Sci. USA, 104:11832-11837, 2007
Gao, J.; Mammen, M.; Whitesides, G. M., "Evaluating Electrostatic Contributions to Binding with the Use of Protein Charge Ladders" Science, 272/5261:535-537, 1996
Nasongkla N, Bey EA, Ren J, Ai H, Khemtong C, Setti JG, Chin SF, Sherry AD, Boothman DA, Gao J, "Multifunctional Polymeric Micelles as Cancer-Targeted, MRI-Ultrasensitive Drug Delivery Systems" Nano Letters, 6:2427-2430, 2006
Ai, H.; Flask, C.; Weinberg, R.; Shuai, X.; Pagel, M.; Farrell, D.; Duerk, J.; Gao, J., "Magnetite-Loaded Polymeric Micelles as Novel Magnetic Resonance Probes" Adv. Mater., 17:1949-1952, 2003
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