My primary research goal is to study the function of the human brain in order to better understand and treat people who suffer from devastating psychiatric illnesses. The focus of my research is to use brain imaging and brain stimulation to investigate and treat mood disorders such as depression and bipolar affective disorder. Advances in brain imaging techniques are now affording us the opportunity to non-invasively investigate the function [Functional MRI (fMRI) and Near Infrared Spectroscopy (NIRS)], structure [high resolution MRI], and connectivity [Diffusion Tensor Imaging (DTI) and resting state fMRI (rs-fMRI)] of different parts of the brain in health and disease. A related area of my research involves the use of functional MRI to detect deception. In addition to studying the human brain using these techniques, I am also interested in investigating how different brain stimulation techniques [transcranial magnetic stimulation (TMS), deep brain stimulation (DBS), and vagus nerve stimulation (VNS)] can be used to treat mood disorders. With a better understanding of psychiatric brain diseases, psychiatry would be better able to prevent, diagnose, target treatments, evaluate treatments, reduce stigma, and predict outcome. Improving the lives of patients who are unfortunate enough to suffer from a mental illness is the ultimate goal.
RESEARCH INTERESTS
Neuroimaging in Mood Disorders
Brain Stimulation in Mood Disorders
fMRI Detection of Deception
RECENT PUBLICATIONS
Kozel FA and George MS, "Neuroimaging and Depression with Inadequate Treatment Response" Primary Psychiatry, 12:30-34, 2005
Kozel FA, Trivedi MH, Wisniewski SR, Miyahara S, Husain MM, Fava M, Lebowitz B, Zisook S, Rush AJ, "Treatment outcomes in older depressed patients with earlier vs. late onset of first depressive episode: A STAR*D Report, 2007" American Journal of Geriatric Psychiatry, 16 (1):58-64, January 2008
Kozel FA, Johnson KA, Laken SJ, Grenesko EL., Walker J, and George MS, "Can Simultaneously Acquired Electrodermal Activity Improve Accuracy of fMRI Detection of Deception?" Social Neuroscience, (in press 8/2007)
Kozel FA and Trivedi M, "Neuroimage and Crime: Developing a Neuropsychiatric Functional Brain Imaging Test" Neurocase, 14 (1):52-53, 2008
Kozel FA, Johnson KA, Nahas Z, Nakonezny PA, Morgan PA, Anderson BA, Kose S, Li X, Lim K, Trivedi M, George M, "DTI Measures of Prefrontal Cortex White Matter Microstructure after Several Weeks of Daily Left High Frequency rTMS in Outpatients with Major Depression" J ECT, (in press 4/08)
SIGNIFICANT PUBLICATIONS
Kozel FA, Nahas Z, deBrux C, Molloy M, Lorberbaum J, Bohning D, Risch SC, George M, "Coil-Cortex Distance relates to Age, Motor Threshold, and Antidepressant Response to Repetitive Transcranial Magnetic Stimulation" The Journal of Neuropsychiatry and Clinical Neurosciences, 12:376-384, 2000
Kozel FA, George MS, "Meta-Analysis of Left Prefrontal Repetitive Transcranial Magnetic Stimulation (rTMS) to Treat Depression" Journal of Psychiatric Practice, 8:270-275, 2002
Kozel FA, Revell LJ, Lorberbaum JP, Shastri A, Elhai JD, Horner MD, Smith A, Nahas Z, Bohning DE, George MS, "A Pilot Study of Functional Magnetic Resonance Imaging Brain Correlates of Deception in Healthy Young Men" Journal of Neuropsychiatry and Clinical Neurosciences, 16(3):295-305, 2004
Kozel FA, George MS, Simpson K, "Decision Analysis of Cost Effectiveness of Repetitive Transcranial Magnetic Stimulation (rTMS) versus Electroconvulsive Therapy (ECT) for Treatment of Non-psychotic Severe Depression" CNS Spectrums, 9:476-482, 2004
Kozel FA, Johnson KA, Mu Q, Grenesko E, Laken SJ, and George MS, "Detecting Deception using Functional MRI" Biological Psychiatry, 58(8):605-613, 2005
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