Congenital anomalies of the bladder are a common cause of chronic renal failure and urinary incontinence in children. Dr. Wilcox’s laboratory is investigating the impact of excessive stretch on normal and abnormal bladder development. This research involves both laboratory based and clinical studies, specifically looking at the effect of bladder outlet obstruction, spina bifida and anorectal (cloacal) anomalies on bladder function. We hope these studies will improve our understanding of these conditions and direct future treatments.
RESEARCH INTERESTS
Bladder evolution in patients born with anorectal and cloacal anomalies
The effect of stretch on fetal bladder development
RECENT PUBLICATIONS
Yiee J, Wilcox D, "Management of fetal hydronephrosis" Pediatric Nephrology, August 2007
Gundeti MS, Patel Y, Duffy PG, Cuckow PM, Wilcox DT, Mushtaq I, "An initial experience of 100 paediatric laparoscopic nephrectomies with transperitoneal or posterior prone retroperitoneoscopic approach" Pediatric Surgery International, 23 (8):795-799, August 2007
Jenkins D, Bitner-Glindzicz M, Thomasson L, Malcolm S, Warne SA, Feather SA, Flanagan SE, Ellard S, Bingham C, Santos L, Henkemeyer M, Zinn A, Baker LA, Wilcox DT, Woolf AS, "Mutational analyses of UPIIIA, SHH, EFNB2 and HNF1beta in persistent cloaca and associated kidney malformations" Journal of Pediatric Urology, 3(1):2-9, February 2007
Leclair Md, Gundetti M, Kiely EM, Wilcox DT, "The Surgical outcome of total urogenital mobilization for cloacal repair" Journal of Urology, 177(4):1492-5, April 2007
Gundeti MS, Godbole PP, Wilcox DT, "Is bowel preparation required before cystoplaty in children?" Journal of Urology, 176(4 Pt 1):1574-6, discussion 1576-7, October 2006
SIGNIFICANT PUBLICATIONS
Burgu B, Medina Ortiz WE, Pitera JE, Woolf AS, Wilcox DT, "Vascular endothelial growth factor mediates hypoxic stimulated embryonic bladder growth in organ culture" Journal of Urology, 177(4):1552-7, April 2007
Warne SA, Wilcox DT, Creighton S, Ransley PG, "Long-term gynecological outcome of patients with persistent cloaca" J Urol, 170(4 Pt 2):1493-6, October 2003
Smeulders N, Woolf AS, Wilcox DT, "Extracellular matrix protein expression during mouse detrusor development" J Pediatr Surg, 38(1):1-12, January 2003
Warne SA, Wilcox DT, Ledermann SE, Ransley PG, "Renal outcome in patients with cloaca" J Urol, 167(6):2548-51, June 2002
Smeulders N, Woolf AS, Wilcox DT, "Smooth muscle differentiation and cell turnover in mouse detrusor development" J Urol, 167(1):385-390, January 2002
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