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James Willson

 
 
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James Willson, M.D.

 Details of Research

Biographical Sketch Details of Research Personal Overview How to Contact
James Willson
Name:
  James Knox Van Arsdale Willson, M.D.
Endowed Title:
  Lisa K. Simmons Distinguished Chair in Comprehensive Oncology
Academic Title:
  Professor
Primary Appointment:
  Simmons Comprehensive Cancer Center
Secondary Appointment:
  Internal Medicine - Hematology-Oncology
School:
  Southwestern Medical School
Affiliations:
  Simmons Comprehensive Cancer Center
Department Website:
  Simmons Comprehensive Cancer Center
Email:
  James Willson, M.D.
Physician Profile:
  James Willson, M.D.

 RESEARCH INTERESTS
 
Colon cancer
Targeted cancer therapeutics
 
 RECENT PUBLICATIONS
 
Bardelli A, Parsons DW, Silliman N, Ptak J, Szabo S, Saha S, Markowitz S, Willson JK, Parmigiani G, Kinzler KW, Wogelstein B, Velculescu VE, "Mutational analysis of the tyrosine kinome in colorectal cancers" Science, 300/5621:949, May 2003
Black JD, Brattain MG, Krishnamurthi SA, Dawson DM, Willson JKV, "ErbB family targeting." Curr Opin Investig Drugs, 4(12):1451-4, December 2003
Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, Willson JKV, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE, "High frequency of mutations of the PIK3CA gene in human cancers." Science, 304/5670:554, April 2004
Wang Z, Shen D, Parsons DW, Bardelli A, Sager J, Szabo S, Ptak J, Silliman N, Peters BA, van der Heijden MS, Parmigiani G, Yan H, Wang TL, Riggins G, Powell SM, Willson JK, Markowitz S, Kinzler KW, Wogelstein B, Velculescu VE, "Mutational analysis of the tyrosine phosphatome in colorectal cancers." Science, 304/5674:1164-6, May 2004
Yan M, Rerko RM, Platzer P, Dawson D, Willis J, Tong M, Lawrence E, Lutterbaugh J, Lu S, Willson JK, Lui G, Hensold J, Tai HH, Wilson K, Markowitz SD, "15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-Β-induced suppressor of human gastrointestinal cancers." Proc Natl Acad Sci USA, 101/50:17468-73, December 2004
 
 SIGNIFICANT PUBLICATIONS
 
Markowitz S, Wang J, Myeroff l, Parons R, Sun LZ, Lutterbaugh J, Fan RS, Zborowska E, Kinzler KW, Vogelstein B, Brattain M, Willson JKV, "Inactivation of the type II TGF-Β receptor in RER colon cancers with microsatellite instability." Science, 268:1336-8, Spring 1995
Spiro TP, Gerson SL, Liu L, Majka S, Haaga J, Hoppel CL, Ingalls ST, Willson JKV, "O6-Benzylguanine: A clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directed DNA repair." Cancer Research, 59:2402-10, May 1999
Ye SC, Foster JM, Li WH, Liang JR, Zborowska E, Venkateswarlu S, Gong JG, Brattain MG, Willson JKV, "Contextual effects of TGF-Β on the tumorigenicity of human colon carcinoma cells." Cancer Research, 59:4725-31, September 1999
Dowlati A, Haaga J, Remick SC, Spiro TP, Gerson SL, Liu L, Berger SJ, Berger NA, Willson JKV, "Sequential tumor biopsies in early phase clinical trials of anticancer agents for pharmacodynamic evaluation." Clinical Cancer Research, 7:2971-6, October 2001
Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, Willson JKV, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE, "High frequency of mutations of the PIK3CA gene in human cancers." Science, 304/5670:554, April 2004
 
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