The Hedgehog (Hh) and Wnt family of secreted proteins play critical roles in cell fate decision-making during embryogenesis and post-embryonic tissue homeostasis in metazoan animals. Misregulation of their pathway responses commonly results in malformations or cancer. Our research program incorporates functional genomics- and biochemically-based approaches to understand how signaling molecules such as Hh and Wnt are conveyed from producing to responding cells and then elicit signals that traverse the responding cell membrane to regulate intracellular effectors. More broadly, we hope to understand how information from multiple signaling molecules including Hh and Wnt integrate in developmental and disease-related contexts.
RESEARCH INTERESTS
signal transduction
signaling networks
Hedgehog and Wingless
RECENT PUBLICATIONS
Zhang C, Williams EH, Guo Y, Lum L, and Beachy PA., "Extensive phosphorylation of Smoothened in Hedgehog pathway activation." PNAS, 101:17897-17899, December 2004
Dorner S, Lum L, Kim M, Paro R, Beachy PA, Green R, "A genomewide screen for components of the RNAi pathway in Drosophila cultured cells" PNAS, 103(32):11880-5, August 2006
Yao S, Lum L, and Beachy PA, "The ihog cell-surface proteins bind Hedgehog and mediate pathway activation" Cell, 125(2):343-57, April 2006
Echeverri CJ, Beachy PA, Baum B, Boutros M, Buchholz F, Chanda SK, Downward J, Ellenberg J, Fraser AG, Hacohen N, Hahn WC, Jackson AL, Kiger A, Linsley PS, Lum L, Ma Y, Mathey-Prevot B, Root DE, Sabatini DM, Taipale J, Perrimon N, Bernards R, "Minimizing the risk of reporting false positives in large-scale RNAi screens" Nat Methods, 3(10):777-9, October 2006
Ma Y, Creanga A, Lum L, and Beachy PA, "Prevalence of off-target effects in Drosophila RNAi screens" Nature, 443(7109):359-63, September 2006
SIGNIFICANT PUBLICATIONS
Lum L, Yao S, Mozer B, Rovescalli A, Von Kessler D, Nirenberg M, Beachy PA, "Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells" Science, 299 (5615):2039-45, March 2003
Lum L, and P.A.Beachy, "The Hedgehog Response Network: Sensors, Switches, and Routers" Science, 304:1755-1759, June 2004
Lum L, Zhang C, Oh S, Mann R, Von Kessler DP, Taipale J, Weis-Garcia F, Gong R, Wang B, Beachy PA, "Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2" Mol Cell, 12:1261-1274, November 2003
Point and right click (click and hold for Mac users) your mouse onand select "Save this link (or target) as..." option to save the file to your local computer.
and select "Save this link (or target) as..." option to save the file to your local computer.