I am investigating various ways to improve statistical methodologies in neuro imaging (fMRI, ASL, PET, SPECT). This includes improvements in image pre-processing, brain mapping, and analysis techniques. The multiple comparisons problems plagues most current methods since there are literally hundreds of thousands of statistical tests. My general approach is to greatly reduce the number of comparisons by reducing the number of tests several orders of magnitude using spatial modeling (kriging) to obtain independent data summaries. I have also published a specific brain mapping improvement in a standardized space and am currently working on a project that promises to surpass that effort.
Besides neuro imaging, I also continue to conduct research in nonparametric statistics. A technique I have dubbed far casting cross validation (FCCV) improves ordinary cross validation in the face of serial/spatial correlation in the nonparametric regression setting for bandwidth selection. I am researching ways to improve FCCV working with a data driven continuous weighting mechanism. I have also developed multivariate response versions of univariate recursive partitioning classification methods and continue developing source code for a library of related functions.
RESEARCH INTERESTS
Multivariate nonparametric function estimation
Statistical computing
Discrimination and classification
Multivariate statistics/data mining
Spatial modeling
RECENT PUBLICATIONS
Carmack, P.S., Schucany, W.R., Spence, J.S., Gunst, R.F., Lin, Q., Haley, R.W., "Far Casting Cross Validation" Journal of Computational and Graphical Statistics, To appear. 2008
Haley, R.W., Spence, J.S., Carmack, P.S., Gunst, R.F., Schucany, W.R., Petty, F., Devous, Sr., M.D., Bonte, F.J., Trivedi, M.H., "Abnormal Brain Response to Cholinergic Challenge in Chronic Encephalopathy from the 1991 Gulf War" Psychiatry Research: Nueroimaging, To appear. 2008
Spence, J., Carmack, P.S., Gunst, R.F., Schucany, W.R., Woodward, W.A., and Haley,, "Accounting for Spatial Dependence in the Analysis of SPECT Brain Imaging" Journal of the American Statistical Association, Vol. 102, No. 478:464-473, 2007
Spence, J., Carmack, P.S., Gunst, R.F., Schucany, W.R., Woodward, W.A., and Haley,, "Using a White Matter Reference to Remove the Dependency of Global Signal" NeroImage, 32:49-53, 2006
Carmack PS, Spence J, Gunst RF, Schucany WR, Woodward WA and Haley RW, "Improved agreement between Talairach and MNI coordinate spaces in deep brain regions" NeuroImage, 22:367-71, 2004
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