Igor Butovich, Ph.D.
Associate Professor
School Medical School
Department Ophthalmology
Graduate Programs Biological Chemistry
Biography
Education
- Graduate School
- Taras Shevchenko National Univ (1981), Biochemistry
- Graduate School
- Taras Shevchenko National Univ (1981), Biology
- Graduate School
- National Academy of Sciences (1985), Chemistry
- Graduate School
- National Academy of Sciences (1985), Enzymology
Research Interest
- Biochemistry, Physiology, and Pathophysiology of the Eye and Adnexa
- Chemistry, Biochemistry, and Biophysics of Lipids
- Chemistry, Biochemistry, and Biophysics of the Tear Film and Meibum
- Drug Discovery
- Enzymology
- Genomics and Metabolomics of the Eye and Adnexa
- Meibomian Gland Studies
Publications
- Forward genetic screening using fundus spot scale identifies an essential role for Lipe in murine retinal homeostasis
- Yuksel S, Aredo B, Zegeye Y, Zhao CX, Tang M, Li X, Hulleman JD, Gautron L, Ludwig S, Moresco EM, Butovich IA, Beutler BA, Ufret-Vincenty RL Communications Biology 2023 Dec 6
- Primary cilia control cellular patterning of Meibomian glands during morphogenesis but not lipid composition
- Portal C, Lin Y, Rastogi V, Peterson C, Yiu SC, Foster JW, Wilkerson A, Butovich IA, Iomini C Communications Biology 2023 Dec 6
- Dysregulation of Lipid Metabolism in Aging Meibomian Glands and Its Molecular Markers
- Butovich IA, Wilkerson A, Yuksel S International journal of molecular sciences 2023 Sep 24
- Comparative Biophysical Study of Meibomian Lipids of Wild Type and Soat1-Null Mice: Implications to Meibomian Gland Dysfunction and Dry Eye Disease
- Xu X, Wilkerson A, Li G, Butovich IA, Zuo YY Investigative Ophthalmology and Visual Science 2023 Aug 64
- Sdr16c5 and Sdr16c6 control a dormant pathway at a bifurcation point between meibogenesis and sebogenesis
- Butovich IA, Wilkerson A, Goggans KR, Belyaeva OV, Kedishvili NY, Yuksel S Journal of Biological Chemistry 2023 Jun 299
- Probing dietary triacylglycerol metabolism and meibogenesis in mice: A stable isotope-labeled tracer liquid chromatography–tandem mass spectrometry study
- Butovich IA, Yuksel S, Wilkerson A Journal of Biological Chemistry 2023 Apr 299
- Dynamic Changes in the Gene Expression Patterns and Lipid Profiles in the Developing and Maturing Meibomian Glands
- Butovich IA, Wilkerson A International journal of molecular sciences 2022 Jul 23
- Novel Lipids of the Rabbit Harderian Gland Improve Tear Stability in an Animal Model of Dry Eye Disease
- Butovich IA, Yuksel S, Leonard B, Gadek T, Polans AS, Albert DM Journal of Ocular Pharmacology and Therapeutics 2021 Dec 37 545-555
- Effects of aging on human meibum
- Butovich IA, Suzuki T Investigative Ophthalmology and Visual Science 2021 Sep 62
- Differential effects of dietary cholesterol and triglycerides on the lipid homeostasis in Meibomian glands
- Butovich IA, Wilkerson A, Yuksel S Journal of Steroid Biochemistry and Molecular Biology 2021 Jul 211
Honors & Awards
- Current NIH award
R01EY027349 (2017-2026) - NIH R01 research awards (recent)
R01EY019480; R01EY024324 (2010-2021) - The Royal Society of Medicine, London, United Kingdom
Overseas Fellow (2010) - National Academy of Sciences, Ukraine
Senior Research Fellow, Bioorganic Chemistry (1997)
Professional Associations/Affiliations
- Association for Research in Vision and Ophthalmology (ARVO) (2005)
- International Society for Eye Research (ISER) (2014)
- The American Society for Biochemistry and Molecular Biology (2022)