Current research interests are (1) fMRI studies of language, of pain and its perception, of sensory and motor activity, and of memory and emotion applied to diagnosis and monitoring of rehabilitation in patients suffering from Gulf War illness, stroke, Alzheimer’s Disease, traumatic brain injury (TBI), and Prkisnon’s and Huntington’s diseases; (2) temporal aspects and nonlinear effects in BOLD responses in functionally connected regions of the brain; (3) methods for reducing motion and susceptibility artifacts in fMRI; (4) integration of EEG and NIRS and other methods with MRI to assess brain function; (5) design and integration of stimulus delivery and task monitoring devices for fMRI; (6) perfusion, diffusion, and 23Na MRI to characterize stroke and track connectivity in the brain; (7) MR spectroscopic imaging of brain metabolites; (8) reduction of acoustic noise in MRI; (9) measurements and mechanisms of MR relaxation; (10) radio frequency coil design; and (11) pulse sequence development.
RESEARCH INTERESTS
functional magnetic resonance imaging (fMRI) of the brain
K.K. Peck, A.B. Moore, B.A. Crosson, M. Gaiefsky, K.S. Gopinath, K. White, and R.W. Briggs, "Functional Magnetic Resonance Imaging Before and After Aphasia Therapy: Shifts in Hemodynamic Time to Peak During an Overt Language Task" Stroke, 35:554-559, 2004
B. Crosson, A.B. Moore, K. Gopinath, K.D. White, C.E. Wierenga, M.E. Gaiefsky, K.R. Fabrizio, K.K. Peck, D. Soltysik, C. Milsted, R.W. Briggs, T.W. Conway, and L.J. Gonzalez Rothi, "Role of the Right and Left Hemispheres in Recovery of Function during Treatment of Intention in Aphasia" J. Cogn. Neurosci., 17:392-406, 2005
B. Crosson, K. McGregor, K.S. Gopinath. T.W. Conway. M. Benjamin, Y.-L. Chang, A.B. Moore, A.M. Raymer, R.W. Briggs, M.G. Sherod, C.E.Wierenga, and K.D. White, "Functional MRI of Language in Aphasia: A Review" Neuropsychol. Rev., 17:157?177, 2007
A. Gholipour, N. Kehtarnavaz, R. Briggs, M. Devous, K. Gopinath, "Brain Functional Localization: A Survey of Image Registration Techniques" IEEE Trans. Med. Imaging, 26 (4):427-451, 2007
C.E. Wierenga, L.M. Maher, A.B. Moore, K.D. White, K. McGregor, D.A. Soltysik, K.K. Peck, K.S. Gopinath, F. Singletary, L.J. Gonzalez-Rothi, R.W. Briggs, and B. Crosson, "Neural Substrates of Syntactic Mapping Treatment: An fMRI Study of Two Cases" J. Intl. Soc. Neuropsych. (JINS), 12:132-146, 2006
SIGNIFICANT PUBLICATIONS
E.A. Shoubridge, R.W. Briggs, and G.K. Radda, "31P NMR Saturation Transfer Measurements of the Steady State-Rates of Creatine Kinase and ATP Synthetase in the Rat Brain" FEBS Letters, 140:288-292, 1982
H.L. Kantor, R.W. Briggs, K.R. Metz, and R.S. Balaban, "Gated in Vivo Examination of Cardiac Metabolites with 31P Nuclear Magnetic Resonance" Amer. J. Physiol, 251:H171-H175, 1986
R.S. Balaban, H.L. Kantor, L. Katz, and R.W. Briggs, "Relation Between Work and Phosphate Metabolites in the in Vivo Paced Mammalian Heart" Science, 232:1121-1123, 1986
Q.X. Yang, M.B. Smith, R.W. Briggs, and R.E. Rycyna, "T2*-Weighted Microimaging at 14 Tesla Using GESEPI for Removal of Magnetic Susceptibility Distortion" J. Magn. Reson., 141:1-6, 1999
M.A. Cato, B. Crosson, D. Gokcay, D. Soltysik, C. Wierenga, K. Gopinath, N. Himes, H., "Processing Words with Emotional Connotation: an fMRI Study of Time Course and Laterality in Rostral Frontal and Retrosplenial Cortices" J. Cogn. Neurosci., 16(2):167-177, 2004
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