Dr. Levitz has a background in the field of drug discovery. She has been at UT Southwestern since 2003, when she joined the Alliance for Cellular Signaling (AfCS) to participate in the AfCS single and dual ligand screen program, studying the release of cytokines by macrophages in response to combinations of ligands. Currently, she is involved in the study of neurogenic inflammatory amplification. Her work examines recently discovered observation that neurokinins are essential for the progression of inflammation in the mammalian aerodigestive track. Moreover, injuries caused by immune complex or stretch-mediated pulmonary require simultaneous expression of preprotachykninin-A gene (PPT-A) by C-fibers and hemopoietic cells. Dr. Levitz is studying the mechanisms underpinning synergy between nerve and hemopoietic cells and how neurokinins participate in this synergy.
RESEARCH INTERESTS
Signal Transduction
Drug Discovery
Biotechnology
RECENT PUBLICATIONS
Han H, Fulin B, Sorrells L, Levitz R, Sinkovits R, and Mumby S., "Introduction to the AfCS Antibody Database: Tabulation of Our Experience with Commercially Available Antibodies." AfCS Research Reports, 1(7); doi: 10:1038, 2003
Levitz, R., Jeng, S.-W., Chen, C.-R., Wang, J. W., and K. Drlica, "Cytotoxic hammerhead ribozymes." Antisense & Nuc. Acid Drug Dev., 9:117-123, 1999
Qiu. L, Moreira, A., Kaplan, G., Levitz, R., Wang, J.-Y., Xu, C., and K. Drlica, "Degradation of Hammerhead ribozymes by human ribonucleases." Mol. Gen. Genet, 258,:352-362, 1998
SIGNIFICANT PUBLICATIONS
Levitz, R., K. Drlica and E. Murphy, "HIV-1 integrase blocks bacterial infection by single-stranded DNA and RNA bacteriophages" Mol. Gen. Genet, 243:417-425, 1994
Levitz, R., J-Y Wang, M. Sioud, K. Drlica, "Expression of functional ribozyme in bacteria" Methods: A Companion to Methods in Enzymology; edited by J. Rossi, 5:29-35, 1993
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