Traumatic brain injury is a significant cause of mortality and morbidity in children over the age of 1 year. With the advancement of non-invasive imaging techniques such as functional MRI and MRI spectroscopy new knowledge can be gained as to the primary pathophysiology and functional outcome of children with TBI. My primary goal is to establish reliable imaging biomarkers that can assist in the development of future clinical trials and investigations in the acutely injured brain. A complimentary research interest is the investigation of the response of neural stem and progenitor cells after neural insult in the developing brain and their potential for participating in self-repair.
RESEARCH INTERESTS
Traumatic Brain Injury
MRI imaging Biomarkers of Neuronal Injury
Neural Stem Cells
RECENT PUBLICATIONS
Miles D.K., Kernie S.G., "Activation of neural stem and progenitor cells after brain injury" Progress in Brain Research, Vol. 157:187-198, Fall 2006
Shi J., Miles D.K., Orr B.A., Massa S.A., Kernie S.G, "Injury induced neurogenesis in Bax- deficient mice: evidence for regulation by voltage-gated potassium channels" European Journal of Neuroscience, Vol. 25:pp. 3499-3512, June 2007
Koch JD, Miles DK, Gilley JA, Yang CP, Kernie SG., "Brief exposure to hyperoxia depletes the glial progenitor pool and impairs functional recovery after hypoxic-ischemic brain injury" Journal of Cerebral Blood Flow and Metabolism, 28(7):1294-306, July 2008
Miles DK, Chen Y, Hoang T, Shi J, Hurlock E, Kernie SG, Lu R., "The Basic Helix-Loop-Helix Transcription Factor Olig2 Is Critical for Reactive Astrocyte Proliferation after Cortical Injury" Journal of Neuroscience, 28(43):10983-10989, October 2008
SIGNIFICANT PUBLICATIONS
Miles DK., Kernie SG., "Hypoxic-ischemic brain injury activates early hippocampal stem/progenitor cells to replace vulnerable neuroblasts" Hippocampus, 18(8):793-806, April 2008
Miles DK, Freedman MH, Stephens K, Pallavicini M, Sievers EL, Weaver M, Grunberger T, Thompson P, Shannon KM., "Patterns of hematopoietic lineage involvement in children with neurofibromatosis type 1 and malignant myeloid disorders" Blood, 88(11):4314-4320, December 1996
Point and right click (click and hold for Mac users) your mouse onand select "Save this link (or target) as..." option to save the file to your local computer.
and select "Save this link (or target) as..." option to save the file to your local computer.