Primary Investigator: Stevo Julius, MD National Study Coordinator: Shawna D. Nesbitt, MD, MS Sponsor: AstraZeneca Pharmaceutical Inc.
This project is a prospective randomized placebo-controlled trial of monotherapy with an angiotensin receptor blocker (ARB) in 809 subjects with high-normal blood pressure at 71 U.S. sites.
Oxidative Stress and Genetics of Prehypertension
Primary Investigator: Shawna D. Nesbitt, M.D. Sponsor: National Institute of Health
This study is designed to examine the role of oxidative stress as assessed by F2-isoprostanes and glutathione ratio in the development of hypertension amongst individuals with high-normal blood pressure. Further, it will assess the role of genetic polymorphisms in the pathways of oxidative stress, renin angiotensin, and nitric oxide in the progression to hypertension.
Dallas Heart Study: A Random Population Sample for Preventing ASHD (Project I)
Cohort Follow-up Coordinator, Project 1: Shawna D. Nesbitt, MD, MS Sponsor: Donald W. Reynolds Foundation
Project 1: To demonstrate that an academic medical center with its surrounding community, can be transformed into a powerful partnership for transitional research leading to the prevention of atherosclerotic heart disease.
Avoiding Cardiovascular Events Through Combination Therapy In Patients Living With Systolic Hypertension" (ACCOMPLISH)
Principal Investigator: Shawna D. Nesbitt, MD Sponsor: Novartis Pharmaceuticals Corp.
A prospective and randomized trial to compare the effects of Lotrel (amlodipine/benazepril) to benazepril and hydrochlorothiazide combined on the reduction of cardiovascular morbidity and mortality in patients with high risk hypertension
IMPACT Study Principal Investigator: Shawna D. Nesbitt MD, MS Sponsor: Investigator Initiated Proposal funded by Pfizer Pharmaceuticals This is a prospective randomized, open label study designed to evaluate the effect of combination once daily therapy for hypertension and lipids with home blood pressure assessment on the control of hypertension in a clinic population of indigent, complicated hypertensive patients. This study will enroll patients from Parkland Hospital to a protocol which includes the use of home and ambulatory blood pressure monitoring to improve blood pressure control.
RESEARCH INTERESTS
Oxidative Stress and Genetics of Prehypertension
Hypertension
Hypertension in African-Americans
Hyperlipidemia
RECENT PUBLICATIONS
Palatini P, Tikhonoff V, Krause L, Amerena J, Nesbitt S, et al., "Genetic contribution to the variance in left ventricular mass: the Tecumseh offspring study." J Hypertens, 19(7):1217-1222, July 2002
Nesbitt, S, "Obesity: Putting Our Children at Risk." Ethn & Dis, 12(3):320-321, Summer 2002
Skov K, Julius S, Nesbitt S, Mulvany MJ, "Can hypertension be prevented? The Danish Hypertension Prevention Project and the Trial of Prevention of Hypertension studies." Curr Opin Cardiol, 17(4):380-384, July 2002
Nesbitt SD, Julius S, "Prehypertension: A Possible Target for Antihypertensive Medication." Curr Hypertens Reports, 2(4):356-361, 2000
SIGNIFICANT PUBLICATIONS
Nesbitt S, Baganz M, "Stroke. Increasing the odds in your favor." In: Crute S (ed), Health and Healing for African Americans. Pennsylvania, Rodale Press, Inc., 1st ed.:428-433, 1997
Nesbitt SD, Amerena JV, Grant E, Jamerson KA, Lu H, Weder A, Julius S, "Home blood pressure as a predictor of future blood pressure stability in borderline hypertension." Am J Hypertens, 10(11):1270-1280, 1997
Julius S, Nesbitt SD, Brook R, "Mild Hypertension: An Importance Frontier in Therapy of Hypertension." in Oparil S, Weber M (ed), Hypertension: A Companion to Brenner and Rector's "The Kidney", Chapter 42:398-404, 2000
Smith [Nesbitt] S, Julius S, Jamerson K, Amerena J, Schork N, "Hematocrit levels and physiologic factors in relationship to cardiovascular risk in Tecumseh, Michigan." J Hypertens, 12(4):455-462, 1994
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