My lab has two foci, first, the control and function of sleep/wake states and second, circuit and system mechanisms of NMDA-hypofunction related cognitive deficits. With regard to sleep/wake states, our work derives in large part from the hypothesis that local extracellular adenosine concentration, reflective of the ratio of metabolic demand to metabolite availability, within the arousal centers will increase with sleep deprivation and facilitate the transition from waking to sleep by inhibition of the neuronal activity of the arousal centers. Thus, even though the effect is a local one, controlled by local factors, because of the global influence of the arousal centers, the effect is a global one. Our second focus is motivated in part by the best pharmacological model of schizophrenia being a blockade of NMDA receptors by ketamine, MK801, or PCP, all NMDA receptor open channel blockers. We have begun an analysis of mechanisms responsible for deficits in neuronal circuit and cognitive systems functions related to NMDA receptor dependent hypofunction in the hippocampus. Our approach involves both in vivo & in vitro electrophysiological recordings combined with inducible gene deletion techniques.
RESEARCH INTERESTS
Molecular, cellular and circuit neurophysiology of behavioral state control
Molecular, cellular and circuit pathophysiology of schizophrenia
Molecular, cellular and circuit dysfunction in PTSD
RECENT PUBLICATIONS
Greene, R.W., "Circuit Analysis of NMDAR Hypofunction in the Hippocampus, In Vitro, and Psychosis of Schizophrenia" Hippocampus, 11:569-577, 2001
Scammel, T.E., Arrigoni E., Thompson, M.A., Ronan, P.J., Saper, C.B., Greene R.W., "Focal Deletion of the adenosine A1 receptor in adult mice using an adeno-associated viral vector." J. Neurosci, 23:5762-5770, 2003
Tarek Rajji1, David Chapman1, Howard Eichenbaum2 and Robert Greene1, "The Role of CA3 Hippocampal NMDA Receptors in Paired Associate Learning" Journal of Neuroscience, 26 (3):908-915, 2006
Brambillo D., Chapman D., Greene R, "Adenosine mediation of presynaptic feedback inhibition of glutamate release" Neuron, 46:275-283, April 2005
Berke JD, Hetrick V, Breck J, Greene RW., "Transient 23-30 Hz oscillations in mouse hippocampus during exploration of novel environments" Hippocampus, 18:519-29, 2008
Berke JD, Hetrick V, Breck J, Greene RW., "Transient 23-30 Hz oscillations in mouse hippocampus during exploration of novel environments." Hippocampus, 18(5):519-29, 2008
Berke JD, Hetrick V, Breck J, Greene RW., "Transient 23-30 Hz oscillations in mouse hippocampus during exploration of novel environments." Hippocampus, 18(5):519-29, 2008
Berke JD, Hetrick V, Breck J, Greene RW., "Transient 23-30 Hz oscillations in mouse hippocampus during exploration of novel environments." Hippocampus, 18(5):519-29, 2008
Berke JD, Hetrick V, Breck J, Greene RW., "Transient 23-30 Hz oscillations in mouse hippocampus during exploration of novel environments." Hippocampus, 18(5):519-29, 2008
SIGNIFICANT PUBLICATIONS
Chen, C., Rainnie, D.G., Greene, R.W. and Tonnegawa, S., "Abnormal fear response and aggressive behavior in mutant mice deficient for CaM kinase II" Science, 266:291-294, 1994
Grunze, H.C.R., Rainnie, D.G., Hasselmo, M.E., Barkai, E., Hearn, E.F., McCarley, R.W., Greene, R.W., "NMDA-dependent modulation of CA1 local circuit inhibition" J.Neurosci., 16(6):2034-43, 1996
Bergeron, R., Coyle, J.T., and Greene, R.W., "Modulation of N-methyl-d-aspartate recepotor function by glycine transport" P.N.A.S., 95:15730-15734, 1998
Brambillo D., Chapman D., Greene R, "Adenosine mediation of presynaptic feedback inhibition of glutamate release" Neuron, 46:275-283, April 2005
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