My research focuses on the role that mediators of developmental neuroplasticity play in adult neuroplasticity.
Inability of the brain to "adapt" may contribute to - or exacerbate - myriad psychiatric disorders.
The main mediators of neuroplasticity we study are new neurons in the adult brain, or adult neurogenesis, and growth factors.
To this extent, we study how chronic exposure to drugs of abuse regulate adult neurogenesis; the role of growth factors in depression and motivation, and the regulation of adult neurogenesis in an animal model of Alzheimer's Disease. For more on my laboratory's research, please visit the Eisch Lab Website at www3.utsouthwestern.edu/eisch/
Mandyam CD, Crawford E, Lee S, Eisch AJ, Rivier CL and Richardson HN, "Prenatal stress differentially impacts hippocampal immature neuron phenotype and microenvironment in adult male and female offspring." Developmental Neurobiology, In Press
Lagace DC, Fischer SJ, Eisch AJ., "Influence of gender and endogenous levels of estradiol on adult hippocampal neurogenesis in mice." Hippocampus, 17:175-180, 2007
Mandyam CD, Harburg GC and Eisch AJ, "Determination of key technical aspects of precursor detection and division in the adult mouse subgranular zone." Neuroscience, 146:108-122, 2007
32) Lagace DC, Whitman MC, Noonan MA, Ables JL, DeCarolis NA, Arguello AA, Donovan MH, Fischer SJ, Farnbauch LA, Beech RD, Dileone RJ, Greer CA, Mandyam CD, Eisch AJ., "Dynamic contribution of nestin-expressing stem cells to adult neurogenesis." The Journal of Neuroscience., 27:12623?12629, 2007
30) Krishnan V, Han M-H, Graham D, Berton O, Renthal W, Laplant Q, Graham A, Russo S, Lutter M, Lagace DC, Ghose S, Reister R, Tannous P, Green T, Neve R, Chakravarty S, Eisch AJ, Self DW, Lee F, Tamminga C, Cooper D, Gershenfeld H, Nestler EJ., "Molecular Mechanisms of Resilience in Brain Reward Regions." Cell, doi:10.1016:j.cell.2007.09.018, 2007
SIGNIFICANT PUBLICATIONS
Messer CJ, Eisch AJ, Carlezon WA, Whisler K, Shen L, Wolf DH, Westphal H, Collins F, Russell DS, Nestler EJ, "Role for GDNF in biochemical and behavioral adaptations to drugs of abuse" Neuron, 26:1-20, 2000
Eisch AJ, Barrot M, Schad CA, Self DW, Nestler EJ., "Opiates inhibit neurogenesis in the adult rodent dentate gyrus" Proceedings of the National Academy of Sciences, USA, 97:7579-7584, 2000
Lagace DC, Yee JK, Bolanos CA, Eisch AJ, "Juvenile administration of methylphenidate attenuates adult hippocampal neurogenesis." Biological Psychiatry, 60:1121-1130, 2006
Harburg GC, Hall FS, Harrist AV, Sora I, Uhl GR, Eisch AJ, "Knockout of the mu opioid receptor enhances survival of adult-generated hippocampal granule cell neurons." Neuroscience, 144:77-87, 2006
Noonan MA, Choi K-H, Self DW, Eisch AJ., "Withdrawal from cocaine self-administration enhances hippocampal neurogenesis, but normalizes proliferation and maturation of neural progenitors, in the adult dentate gyrus subgranular zone" The Journal of Neuroscience, 28:2516-26, 2008
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