Study of the lipodystrophy syndromes as a model to understand the mechanisms of insulin resistance. Particular interest in the role of leptin as a mediator between fat and insulin action, and in its potential therapeutic role. Involved in clinical trials of recombinant leptin therapy for patients with lipodystrophy. Have also been working on trying to understand the mechanism of HIV-associated lipodystrophy, and its therapeutic options.
RESEARCH INTERESTS
Lipodystrophy syndromes
Leptin biology and therapeutics
RECENT PUBLICATIONS
Simha V, Garg A., "Body fat distribution and metabolic derangements in patients with Familial Partial Lipodystrophy associated with Mandibuloacral Dysplasia" J Clin Endocrinol Metab, 87:776-785, 2002
Simha V, Zerwekh JA, Wagner A, DePaoli A, Sakhaee K, Garg A, "Effect of leptin replacement therapy on bone metabolism" J Clin Endocrinol Metab, 87(11):4942-4945, 2002
Simha V, Szczepaniak LS, Wagner A, DePaoli A, Garg A, "Effect of leptin replacement on intrahepatic and intramyocellular lipid content in patients with generalized lipodystrophy" Diabetes Care, 26(1):30-35, 2003
Simha V, Agarwal AK, Oral EA, Fryns JP, Garg A, "Genetic and phenotypic heterogeneity in patients with mandibuloacral dysplasia-associated lipodystrophy" J Clin Endocrinol Metab, 88(6):2821-2824, 2003
SIGNIFICANT PUBLICATIONS
Agarwal AK, Simha V, Oral EA, Moran SA, Gorden P, O’Rahilly S, Zaidi Z, Gurakan F, Arslanian SA, Klar A, Ricker A, White NH, Bindl L, Herbst K, Kennel K, Patel SB, Al-Gazali L, Garg A., "Phenotypic and genetic heterogeneity in congenital generalized lipodystrophy" J Clin Endocrinol Metab, 88(10):4840-4847, 2003
Simha V, Garg A., "Phenotypic heterogeneity in body fat distribution in patients with congenital generalized lipodystrophy caused by mutations in the AGPAT2 or seipin genes." J Clin Endocrinol Metab, 88(11):5433-5437, 2003
Simha V, Garg A, "Lipodystrophy: lessons in lipid and energy metabolism." Current Opinion in Lipidology, 17:162-169, 2006
2. Oral EA, Simha V, Ruiz E, Sebring N, Andewelt A, Premkumar A, Snell P, Wagner A, DePaoli A, Reitman ML, Taylor SI, Gorden P, Garg A, "Leptin replacement therapy for lipodystrophy." N Engl J Med, 346:570-578, 2002
Point and right click (click and hold for Mac users) your mouse onand select "Save this link (or target) as..." option to save the file to your local computer.
and select "Save this link (or target) as..." option to save the file to your local computer.