To study ligand gating of cation channels mainly via X-ray crystallography.
RECENT PUBLICATIONS
Shi N, Ye S, Alam A, Chen L, Jiang Y, "Atomic structure of a Na+- and K+-conducting channel." Nature, 440(7083):570-4, March 2006
Ye S, Li Y, Chen L, Jiang Y, "Crystal structures of a ligand-free MthK gating ring: insights into the ligand gating mechanism of K+ channels." Cell, 126(6):1161-73, September 2006
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