Research on the genetics of the Human Leukocyte Antigens (HLA), specifically the study of MICA and MICB antigens encoded in the human Major Histocompatibility Complex (MHC). These recently described molecules are of interest because of their polymorphism and predominant expression in endothelial cells, monocytes, fibroblasts and epithelial cells including keratinocytes. The possible role of MICA antigens in HCMV infection and their capacity to induce the production of alloantibodies and possibly serve as targets for graft rejection are being investigated.
RESEARCH INTERESTS
Histocompatibility antigens
Molecular methods for histocompatibility testing
Immunology of allograft rejection
RECENT PUBLICATIONS
Yizhou Zou, Falko Heinemann, Hans Grosse-Wilde, Guido Sireci, Zhengnan Wang, Bhavna Lavingia and Peter Stastny, "Detection of anti-MICA antibodies in patients awaiting kidney transplantation, during the post-transplant course and in eluates from rejected kidney allografts by Luminex flow cytometry" Human Immunology, 67(3):230-7, 2006
Yizhou Zou, Mei Han, Zhengnan Wang and Peter Stastny, "MICA allele-level typing by SBT with computerized assignment of polymorphic sites and short tanden repeats (STRS) within the transmembrane region" Human Immunology, 67(3):145-51, 2006
Yizhou Zou, Fariba Mirbaha and Peter Stastny, "Contact inhibition causes strong down-regulation of expression of MICA and decreased NK cell killing of human fibroblasts" Human Immunology, 67(3):183-7, 2006
Yizhou Zou, Wade Bresnahan, R.Travis Taylor and Peter Stastny, "Effect of human cytomegalovirus on expression of MHC class I-related chain A" The Journal of Immunology, 174(5):3098-104, 2005
Yizhou Zou and Peter Stastny, "Alternatively spliced forms of MICA and MICB lacking exon 3 in a human cell line and evidence of presence of similar RNA in human peripheral blood mononuclear cells" Immunogenetics, 54:671-4, 2002
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