Vascular endothelial cells share both developmental pedigree and expression profile characteristics with myeloid cells, including the elaboration of an oxidant-producing NADPH oxidase. This oxidase appears to participate in several broad signaling pathways. Our work in part focuses on the mechanism by which this oxidase controls cytoskeletal and cell fate signaling in the vascular endothelium.
RESEARCH INTERESTS
Vascular Biololgy
Oxidant Biochemistry
Signal Transduction
Acute Lung Injury
RECENT PUBLICATIONS
Ma, Z., D.P. Myers, R.F. Wu, F.E. Nwariaku, and L.S. Terada., "p66Shc mediates anoikis through RhoA" J. Cell Biol., 179:23, 2007
Wu, R.F., Z. Ma, D.P. Myers, and L.S. Terada., "HIV1 Tat activates dual Nox pathways leading to independent activation of ERK and JNK MAP kinases." J. Biol. Chem., 282:37412, 2007
Nwariaku, F.E., Z. Liu, R.F. Wu, Y. Gu, X. Zhu, G. Sarosi, and L.S. Terada., "The NADPH oxidase mediates TNF-induced VE-cadherin phosphorylation and endothelial barrier dysfunction." Blood, 104:3214-3220, 2004
Wu, R.F., Y. Gu, Y.C. Xu, S. Mitola, F. Bussolino, and L.S. Terada., "Human immunodeficiciency virus type 1 Tat regulates endothelial cell actin cytoskeletal dynamics through PAK1 activation and oxidant production." J. Virol., 78:779-789, 2004
Banerjee, S., E. Brilakis, S. Zhang, M. Roesle, J. Lindsey, B. Philips, C.G. Blewett, and L.S. Terada, "Endothelial progenitor cell mobilization after percutaneous coronary intervention" Atherosclerosis, 189:70-75, 2006
SIGNIFICANT PUBLICATIONS
Terada, L.S., "Specificity in reactive oxidant signaling: Think globally, act locally" J. Cell Biol., 174:615-623, 2006
Wu, R.F., Y.C. Xu, Z. Ma, F.E. Nwariaku, G.A, Sarosi, and L.S. Terada., "Subcellular targeting of oxidants during endothelial cell migration" J. Cell Biol., 171:893, 2005
Y.C. Xu, R.F. Wu, Y. Gu, Y.S. Yang, M.C. Yang, F.E. Nwariaku, L.S. Terada, "Involvement of TRAF4 in oxidative activation of c-Jun amino terminal kinase" J. Biol. Chem, 277:28051-28057, 2002
Gu, Y., Y.C. Xu, R.F. Wu, F.E. Nwariaku, R.F. Souza, S.C. Flores, and L.S. Terada., "p47phox participates in activation of RelA in endothelial cells." J. Biol. Chem., 278:17210-17217, 2003
Wu, R.F., Y. Gu, Y.C. Xu, F.E. Nwariaku, and L.S. Terada, "VEGF causes translocation of p47phox to membrane ruffles through WAVE1." J. Biol. Chem., 278:36830-36840, 2003
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