Research Experience: Principle Investigator: Prowess 15 (301 and 302): Effects of Iloprost compared with placebo on exercise capacity in idiopathic PAH. Actelion, 2008-current
Compass-3: The effectiveness of bosentan alone or in combination with sildenafil on hemodynamics, exercise and cardiac MRI. Actelion, 2006-current.
Sub-investigator: FREEDOM - C Oral Treprostinil in combination with an ERA and/or a PDE-5 Inhibitor for the treatment of PAH United Therapeutics, 2006-current
TRIUMPH I: Double blind placebo controlled clinical investigation into the efficacy and tolerability of inhaled treprostinil sodium in patients with severe pulmonary arterial hypertension. Lung Rx, 2006-current
REVIVE: Intravenous Remodulin as adjunctive therapy to subjects currently receiving sildenafil, bosentan or the combination of sildenafil and bosentan for the treatment of pulmonary arterial hypertension. United Therapeutics, 2005
Ambrisentan: A long-term study of ambrisentan in pulmonary arterial hypertension subjects having completed AMB-320 or AMB-321. Myogen, 2004-2007
Other research: 1) Investigation of BNP level and SVC oxygen saturation as prognostic markers in pulmonary hypertension. 2) Methamphetamine use and risk of pulmonary hypertension 3) MRI variables as markers of prognosis
RESEARCH INTERESTS
Pulmonary Hypertension
RECENT PUBLICATIONS
Chin KM, Kingman M, de Lemos JA, Warner JJ, Reimold S, Peshock R, Torres F., "Changes in right ventricular structure and function assessed by cardiac magnetic resonance imaging in bosentan treated patients with pulmonary arterial hypertension." Am J Cardiology, 101:1669-1672, 2008
Chin K, Channick R, Kim N, Rubin L, "Central venous blood oxygen saturation monitoring in patients with chronic pulmonary arterial hypertension treated with continuous intravenous epoprostenol: correlation with measurements of hemodynamics and plasma brain natriuretic peptide levels." Chest, July 2007
Chin, KM, Channick RN, Rubin LJ, "Pulmonary Hypertension: Diagnosis and Treatment" Manual of Clinical Problems in Pulmonary Medicine, 2004
SIGNIFICANT PUBLICATIONS
Chin KM, Chanick RN, de Lemos JA, Kim NH, Torres F, Rubin LJ., "Hemodynamics and epoprostenol use are associated with thrombocytopenia in pulmonary arterial hypertension." Chest, In Press
Chin KM, Rubin LJ, "Pulmonary Arterial Hypertension" Journal of the American College of Cardiology, 51:1527-1538, March 2008
Chin KM, Channick RN, Rubin LJ, "Is Methamphetamine Use Associated with Pulmonary Arterial Hypertension?" Chest, 130:1657-63, 2006
Chin KM, Kim HS, Rubin LJ, "The Right Ventricle in Pulmonary Hypertension" Coronary Artery Disease, 16:13-18, 2005
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