My clinical and scientific interests revolve around the treatment and management of patients with heart failure and the molecular mechanisms underlying this clinical entity. Scientifically, my laboratory is interested in investigating how regulation of the metabolic and redox states of myocytes can be modulated to serve as potential therapeutic targets for various cardiomyopathies. Specifically, the laboratory is focused on the transcriptional regulation and functional roles of tissue hemoproteins within the heart. These tissue hemoproteins may serve to facilitate oxygen transport, act as oxygen sensors, scavenge free radicals, and/or maintain nitric oxide homeostasis within the cardiomyoctye. Ultimately, the ability to selectively regulate the metabolic and redox states within heart may provide opportunities for the development of novel therapeutic approaches to the treatment of patients with heart failure.
RESEARCH INTERESTS
Modulation of the metabolic and redox states with stressed cardiomyocytes
Oxidative stress
Transcriptional regulation and functional roles of tissue hemoglobins in the heart
Oxygen and nitric oxide metabolism in the heart
Cardiac energetics
RECENT PUBLICATIONS
Singh S.*, S.M. Manda*, D. Sikder, M.J. Birrer, B.A. Rothermel, D.J. Garry, and P.P.A. Mammen., "Calcineurin activates cytoglobin transcription in hypoxic myocytes." Journal of Biological Chemistry, In Press:Online February 9, 2009, February 2009
Patel, P.C., S.A. Murphy, R. Peshock, A. Khera, J.A. de Lemos, J.A. Balko, S Gupta, P.P.A. Mammen, M.H. Drazner, and D.W. Markham., "Association of Cystatin C with left ventricular structure and function: The Dallas Heart Study." Circulation-Heart Failure, In Press:Online February 10, 2009, February 2009
Kanatous, S.B., P.P.A. Mammen, P.B. Rosenberg, C.M. Martin, M.D. White, J.M. DiMaio, G Huang, S. Muallem, and D.J. Garry, "Hypoxia reprograms calcium signaling and regulates myoglobin expression." American Journal of Physiology - Cell Physiology, In Press:Presently online, November 2008
Gupta S., D.W. Markham, M.H. Drazner, and P.P.A. Mammen, "Fulminant myocarditis." Nature Clinical Practice Cardiovascular Medicine, 5(11):693-706, 2008
Mammen P.P.A., J.M Shelton, Q. Ye, S.B. Kanatous, A.J. McGrath, J.A. Richardson, and D.J. Garry, "Cytoglobin: A novel stress-responsive hemoprotein that is expressed in the developing and adult brain." Journal of Histochemistry & Cytochemistry, 54(12):1349-1361, 2006
SIGNIFICANT PUBLICATIONS
Kalaany N.Y, K.C. Gauthier, A.M. Zavacki, P.P.A. Mammen, T. Kitazume, J.A. Peterson, D.J. Garry, A.C. Bianco, and D.J. Mangelsdorf., "LXRs: Double agents in the regulation of dietary fat and cholesterol metabolism." Cell Metabolism, 1:231-244, 2005
Mammen P.P.A., S.B. Kanatous, I. Yuhanna, P. W. Shaul, R.S. Balaban, M.G. Garry, and D.J. Garry, "Hypoxia-induced left ventricular dysfunction in myoglobin deficient mice." Am J Physiol: Heart and Circulatory Physiology, 285:H2132-2141, 2003
Garry D.J., S.B. Kanatous, and P.P.A. Mammen, "Emerging roles of myoglobin in the heart." Trends in Cardiovascular Medicine, 13:111-116, 2003
Meeson A., N. Radford, J.M. Shelton, P.P.A. Mammen, Y.Kong, J.M. DiMaio, K. Hutcheson, J. Elterman, R.S. Williams, and D.J. Garry, "Adaptive mechanisms that preserve cardiac function in mice without myoglobin." Circulation Research, 88:713-720, 2001
Rothermel B.A., T.A. McKinsey, R.B. Vega, R.L.Nicol, P. Mammen, J. Yang, C. Antos, J.M. Shelton, R. Bassel-Duby, E.N. Olson, and R.S. Williams., "Myocyte-enriched calcineurin interacting protein, MCIP1, inhibits cardiac hypertrophy." Proceedings of the National Academy of Sciences USA, 98:3328-3333, 2001
Point and right click (click and hold for Mac users) your mouse onand select "Save this link (or target) as..." option to save the file to your local computer.
