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Xin Zhou

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Xin Zhou, M.D.

Details of Research

Name:		Xin Jin Zhou, M.D.
Endowed Title:		Drs. George and Anne Race Distinguished Professorship of Pathology
Academic Title:		Professor
Primary Appointment:		Pathology
Secondary Appointment:		Internal Medicine
School:		Southwestern Medical School
Affiliations:		Pathology
Department Website:		Pathology
Lab Website:		Veripath Laboratories
Email:		Xin Zhou, M.D.

RESEARCH INTERESTS

	Cellular and Molecular Mechanisms of Hypertension and Renal Diseases
	Pathogenesis of lupus nephritis in murine models of SLE

RECENT PUBLICATIONS

	X,J. Zhou, F.G. Silva, "Membranoproliferative glomerulonephritis" Heptinstall’s Pathology of the Kidney, 6th edition, In Jennette JC, Olson JL, Schwartz MM, Silva FG (eds), 253-319, 2007
	C. Xie, R. Patel, T. Wu, T. J. Zhu, Henry, M. Bhaskarabhatla, R. Samudrala, K. Tus, Y. Gong, H. Zhou, E. Wakeland, X.J. Zhou, C. Mohan (* Co-senior authors), "PI3K/AKT/mTOR hypersignaling in autoimmune lymphoproliferative disease engendered by the epistatic interplay of Sle1b and FASlpr." Int Immunol, 19:509-522, 2007
	X.J. Zhou, D. Rakheja, X.Q. Yu, N.D. Vaziri, F.G. Silva, "Tha aging kidney" Kidney International, 74:710-720, 2008
	J.H. Zhen, H. Lu, X.Q. Wang, N.D. Vaziri, X.J. Zhou, "Upregulation of endothelial nitric oxide synthase in human endothelial cells by reactive oxygen species." Am J Hypertens, 21:28-34, 2008
	X. J. Zhou, Z. G. Laszik, F. G. Silva, "Anatomical changes in the aging kidney" The Aging Kidney in Health and Disease, In Macias-Nunez JF, Cameron JS, Oreopoulos DG (eds), 39-54, 2008

SIGNIFICANT PUBLICATIONS

	N.D. Vaziri, Z. Ni, Z.Q. Wang, F. Oveisi, X.J. Zhou, "Down regulation of nitric oxide synthase in chronic renal insufficiency: role of excess PTH." Am. J. Physiol., 274:F642-F649, 1998
	Z. Lasik, X.J. Zhou, G. Ferrel, F.G. Silva, C.T. Esmon, "Down regulation of endothelial cell protein C receptor and thrombomodulin in coronary atherosclerosis." Am. J. Pathol., 159:797-802, 2001
	Z. Liang, C. Xie, C. Chen, D. Kreska, K. Hsu, L. Li, X.J. Zhou, C. Mohan, "Pathogenic profiles and molecular signatures of antinuclear autoantibodies derived from NZM2410 lupus mice." J. Exp. Med., 199:381-398, 2004
	S. Subramanian, Y. Yim, K. Liu, K. Tus, X.J. Zhou. E.K. Wakeland, "Epistatic Suppression of SLE: Fine mapping of Sles1 to < 1Mb" J. Immunol, 175:1062-1072, 2005
	Y. Fu, C. Xie, J. Chen, J. Zhu, H. Zhou, J. Thomas, X.J. Zhou, "Innate stimuli accentuate end-organ damage by nephrotoxic antibodies via Fc receptor and TLR stimulation and IL-1/TNF-a production" J. Immunol, 176:632-639, 2006

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